Li Shengjie, Wang Yujie, Xuan Zhiqiang, Zhang Yue, Miao Zhongxing
Department of Gastroenterology Surgery, Dalian Municipal Central Hospital, Liaoning, 116033, China.
Ir J Med Sci. 2023 Feb;192(1):89-97. doi: 10.1007/s11845-022-02964-5. Epub 2022 Mar 23.
Homeobox B2 (HOXB2) is known to be correlated with the development and prognosis of various cancers. However, its role in colon cancer remains unclear.
In this study, we explored the prognostic value of HOXB2 in colon adenocarcinoma (COAD).
A total of 264 colon adenocarcinoma cases were retrospectively enrolled to evaluate HOXB2 expression and clinical significance. Chi-square test was applied to identify relationship between clinical features and HOXB2 expression. The effect of HOXB2 expression and clinical features on the survival of COAD patients was evaluated using Kaplan-Meier and Cox regression analyses. Cellular assays and mice models were conducted to validate the tumor-related role of HOXB2 in COAD.
Higher expression of HOXB2 in COAD tissues was significantly associated with tumor size, invasion depth, and lymph node metastasis (all P < 0.05). Univariate and multivariate analyses showed that high expression of HOXB2 was significantly correlated with a poor overall survival. In vitro cellular assays combined with knockdown strategies demonstrated that HOXB2 can promote tumor proliferation and invasion of COAD, which was further confirmed by in vivo xenograft experiments.
HOXB2 may be a valuable biomarker and potential therapeutic target for the treatment of COAD.
已知同源盒B2（HOXB2）与多种癌症的发生发展及预后相关。然而，其在结肠癌中的作用仍不清楚。
在本研究中，我们探讨了HOXB2在结肠腺癌（COAD）中的预后价值。
回顾性纳入264例结肠腺癌病例，以评估HOXB2的表达及临床意义。采用卡方检验确定临床特征与HOXB2表达之间的关系。使用Kaplan-Meier法和Cox回归分析评估HOXB2表达及临床特征对COAD患者生存的影响。进行细胞实验和小鼠模型以验证HOXB2在COAD中的肿瘤相关作用。
COAD组织中HOXB2的高表达与肿瘤大小、浸润深度和淋巴结转移显著相关（均P<0.05）。单因素和多因素分析表明，HOXB2的高表达与较差的总生存期显著相关。体外细胞实验结合基因敲低策略表明，HOXB2可促进COAD的肿瘤增殖和侵袭，体内异种移植实验进一步证实了这一点。
HOXB2可能是治疗COAD的有价值的生物标志物和潜在治疗靶点。
