法国吉伦特省室管膜瘤的描述性流行病学：吉伦特登记处2000 - 2018年期间的结果

Descriptive Epidemiology of Ependymal Tumors in Gironde, France: Results from the Gironde Registry for the 2000-2018 Period.

作者信息

Laine Gaëtan, Baldi Isabelle, Jecko Vincent, Betancourt Zamira, Bertaud Emilie, Huchet Aymeri, Menegon Patrice, Eimer Sandrine, Chotard Guillaume, Cuny Emmanuel, Gimbert Edouard, Liguoro Dominique, Mollier Olivier, Monteil Pascal, Penchet Guillaume, Vignes Jean-Rodolphe, Wavasseur Thomas, Loiseau Hugues, Engelhardt Julien

机构信息

Department of Neurosurgery, CHU de Bordeaux, Bordeaux, France.

Bordeaux Population Health Research Center, Team Epicene, UMR 1219, University of Bordeaux, INSERM, Bordeaux, France.

出版信息

Neuroepidemiology. 2022;56(4):250-260. doi: 10.1159/000523954. Epub 2022 Mar 23.

DOI:10.1159/000523954

PMID:35320802

Abstract

BACKGROUND

The Gironde Central Nervous System (CNS) Tumor Registry, in collaboration with the French National Cancer Institute, is the largest population-based registry focused exclusively on primary CNS tumors in France and represents a population of 1.62 million. This report focuses on ependymal tumors to refine current knowledge and provide up-to-date data on the epidemiology of these rare tumors.

MATERIAL AND METHODS

All of the ependymal tumors were extracted from the Gironde CNS Tumor Registry for the years 2000-2018. Demographic and clinical characteristics, incidence rates, and time trends as well as survival outcomes were analyzed.

RESULTS

One hundred forty-four ependymal tumors were retrieved, which represented 2.3% of all the CNS tumors recorded in the same period. Histological subtype was significantly dependent on age and topography in the CNS. The median age at diagnosis was 46 years. The annual incidence rates varied between 0.15/100,000 (2004) and 0.96/100,000 (2016), with a significant increase over the study period by 4.67% per year. Five-year and 10-year OS rates were 87% and 80%, respectively.

CONCLUSION

An increase in the incidence of ependymal tumors was observed over the past two decades. Further studies are needed to confirm this result and provide etiological clues.

摘要

背景

吉伦特省中枢神经系统（CNS）肿瘤登记处与法国国家癌症研究所合作，是法国最大的专门针对原发性中枢神经系统肿瘤的基于人群的登记处，覆盖人口162万。本报告聚焦室管膜瘤，以完善现有认知，并提供这些罕见肿瘤流行病学的最新数据。

材料与方法

从吉伦特省中枢神经系统肿瘤登记处提取了2000 - 2018年期间所有的室管膜瘤病例。分析了人口统计学和临床特征、发病率、时间趋势以及生存结果。

结果

共检索到144例室管膜瘤，占同期记录的所有中枢神经系统肿瘤的2.3%。组织学亚型在很大程度上取决于患者年龄和中枢神经系统中的肿瘤位置。诊断时的中位年龄为46岁。年发病率在0.15/10万（2004年）至0.96/10万（2016年）之间变化，在研究期间每年显著增加4.67%。5年和10年总生存率分别为87%和80%。