Laboratoire Santé Travail Environnement, Centre INSERM U 897, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux, France.
Neuro Oncol. 2011 Dec;13(12):1370-8. doi: 10.1093/neuonc/nor120. Epub 2011 Oct 6.
An increase in the incidence of CNS tumors has been observed in many countries in the last decades. The reality of this trend has been much debated, as it has happened during a period when computer-assisted tomography and MRI have dramatically improved the detection of these tumors. The Gironde CNS Tumor Registry provides here the first data on CNS tumor incidence and trends in France for all histological types, including benign and malignant tumors, for the period 2000-2007. Incidence rates were calculated globally and for each histological subtype. For trends, a piecewise log-linear model was used. The overall annual incidence rate was found to be 17.6/100 000. Of this rate, 7.9/100 000 were neuroepithelial tumors and 6.0/100 000 were meningiomas. An overall increase in CNS tumor incidence was observed from 2000 to 2007, with an annual percent change (APC) of +2.33%, which was explained mainly by an increase in the incidence of meningiomas over the 8-year period (APC = +5.4%), and also more recently by an increase in neuroepithelial tumors (APC = +7.45% from 2003). The overall increase was more pronounced in women and in the elderly, with an APC peaking at +24.65% in subjects 85 and over. The increase in the incidence rates we observed may have several explanations: not only improvements in registration, diagnosis, and clinical practice, but also changes in potential risk factors.
在过去几十年中，许多国家都观察到中枢神经系统肿瘤的发病率有所增加。这种趋势的真实性存在很大争议，因为它发生在计算机辅助断层扫描和磁共振成像显著提高了这些肿瘤检测能力的时期。吉伦特中枢神经系统肿瘤登记处提供了法国所有组织学类型（包括良性和恶性肿瘤）的中枢神经系统肿瘤发病率和趋势的首批数据，时间范围为 2000 年至 2007 年。发病率是根据全球和每种组织学亚型计算的。对于趋势，使用分段对数线性模型。总体年发病率为 17.6/100000。在这个比率中，7.9/100000 是神经上皮肿瘤，6.0/100000 是脑膜瘤。从 2000 年到 2007 年，中枢神经系统肿瘤的发病率总体呈上升趋势，年变化百分比（APC）为+2.33%，这主要归因于 8 年间脑膜瘤发病率的上升（APC = +5.4%），最近神经上皮肿瘤的发病率也有所上升（APC = +7.45%，从 2003 年开始）。在女性和老年人中，总体上升更为明显，85 岁及以上人群的 APC 峰值为+24.65%。我们观察到的发病率上升可能有几个解释：不仅是登记、诊断和临床实践的改进，还有潜在危险因素的变化。
