Agatha David, Titilola Gbaja-Biamila, Abideen Salako, Oluwatosin Odubela, Agatha Wapmuk, Sabdat Ekama, Tomilola Musari-Martins, Priscilla Ezemelue, Ebiere Herbertson, Oliver Ezechi
Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.
Glob Pediatr Health. 2022 Mar 19;9:2333794X221082784. doi: 10.1177/2333794X221082784. eCollection 2022.
This study aimed to compare growth and pubertal developmental parameters among HIV-infected and uninfected adolescent girls (11-19 years) in Lagos using a cross-sectional approach. Height, weight, BMI -scores, sexual maturity rating by Tanner stages and age at menarche, were compared in the 2 groups. The mean age was similar in both groups (13.2 [±2.3] years and 13.6 [±1.6] years for HIV positive and negative respectively [ = .13]). Majority (66.2%) were in Junior Secondary classes and the mean socioeconomic class was 2.5 (±0.9). HIV-infected girls had significantly lower height, weight, and BMI scores compared to their uninfected counterparts. The proportion that had attained Tanner stages 3 to 5 were significantly lower among the HIV-positive participants. The study identified lower growth parameters and pubertal delay among HIV-infected adolescent females compared to HIV uninfected girls. Growth and sexual maturation assessment should form part of routine care of adolescents living with HIV.
本研究旨在采用横断面研究方法,比较拉各斯地区感染和未感染艾滋病毒的11至19岁青春期女孩的生长发育和青春期发育参数。比较两组的身高、体重、体重指数评分、坦纳分期的性成熟评级和初潮年龄。两组的平均年龄相似(艾滋病毒阳性组为13.2[±2.3]岁,阴性组为13.6[±1.6]岁,P = 0.13)。大多数(66.2%)在初中班级,平均社会经济阶层为2.5(±0.9)。与未感染艾滋病毒的女孩相比,感染艾滋病毒的女孩的身高、体重和体重指数评分显著更低。在艾滋病毒阳性参与者中,达到坦纳3至5期的比例显著更低。该研究发现,与未感染艾滋病毒的女孩相比,感染艾滋病毒的青春期女性的生长参数更低且青春期延迟。生长和性成熟评估应成为艾滋病毒感染青少年常规护理的一部分。