Nagai T, Sakaizumi K, Asanami S, Lian S L, Tomita O, Hirayama T
J Maxillofac Surg. 1978 May;6(2):98-103. doi: 10.1016/s0301-0503(78)80076-9.
"BAR" therapy is a combined therapy with BUdR (Radiosensitizer), Antimetabolites (5-FU, FT-207 etc.) and Radiation for malignant tumours. How radiation can be reduced as far as possible and how the effects of treatment can be increased as much as possible are the objectives of this study of combining radiation and BUdR therapy. The authors attempted to irradiate 3-5 days after the BUdR and antimetabolite had been infused via the superficial temporal artery, in 12 malignant oral tumours (11 squamous cell carcinomas and 1 reticulum-cell sarcoma). BUdR 50-250 mg/day, antimetabolites (5-FU) 10-250 mg/day and a total irradiation dose of 6000 rads by 6 MeV Linac X-ray or Co-60 gamma ray, 200 rads/day were given. 9 marked responses, 2 moderate responses and 1 no response (2 cases were operated on by local resection) were obtained by the authors. Side effects of treatment were observed during the course of "BAR" therapy. Stomatitis was found in all patients and it occurred on the mucosa of the tumour-affected site especially. Dermatitis of the skin of the face was noted in 6 cases, resembling irradiation dermatitis. Fever was observed in 4 cases and it always occurred after irradiation. Diarrhoea was noted in 3 cases and occurred before irradiation, 2 out of 3 were given BUdR 0.1 g and the remaining one was given BUdR 1 g, and 5-FU lg. In addition, there were: 1 loss of appetite, 1 nausea and 1 exfoliation of nails.
“BAR”疗法是一种针对恶性肿瘤的联合疗法，它结合了溴脱氧尿苷（放射增敏剂）、抗代谢药物（5-氟尿嘧啶、替加氟等）以及放疗。本研究联合放疗与溴脱氧尿苷疗法的目的在于尽可能减少辐射剂量，并尽可能增强治疗效果。作者尝试在通过颞浅动脉注入溴脱氧尿苷和抗代谢药物后的3 - 5天，对12例口腔恶性肿瘤（11例鳞状细胞癌和1例网状细胞肉瘤）进行放疗。给予患者溴脱氧尿苷50 - 250毫克/天、抗代谢药物（5-氟尿嘧啶）10 - 250毫克/天，并用6兆电子伏直线加速器X射线或钴-60γ射线进行放疗，总剂量达6000拉德，每日剂量为200拉德。作者观察到9例显著缓解、2例中度缓解和1例无缓解（2例通过局部切除手术治疗）。在“BAR”治疗过程中观察到了治疗的副作用。所有患者均出现口腔炎，尤其发生在肿瘤累及部位的黏膜。6例患者出现面部皮肤皮炎，类似放射性皮炎。4例患者出现发热，且总是在放疗后发生。3例患者出现腹泻，在放疗前发生，其中2例给予0.1克溴脱氧尿苷，另1例给予1克溴脱氧尿苷及1克5-氟尿嘧啶。此外，还有1例食欲不振、1例恶心和1例指甲脱落。
