Department of Nursing Platform for Breast Surgery, The First Hospital of Jilin University, Changchun, China.
Department of Operation Room, The First Hospital of Jilin University, Changchun, China.
J Biomater Sci Polym Ed. 2022 Aug;33(11):1383-1397. doi: 10.1080/09205063.2022.2056942. Epub 2022 Mar 28.
Nanocarrier-based photodynamic therapy (PDT) has emerged as a promising treatment in cancer therapy. However, the PDT therapeutic efficacy is limited by the lack of specificity, limited intracellular cytotoxic reactive oxygen species (ROS) generation, and the immunosuppressive tumor microenvironment. Herein, a platelet membrane (Pm) decorated and chlorin e6 loaded liposome (Pm/Lps/Ce6) is developed to improve specific tumor-targeting capability and antitumor responses. Pm/Lps/Ce6 could efficiently improve the cellular internalization of Ce6. Under 660-nm laser irradiation, enough ROS was produced to suppress the growth of tumor cells . , the Pm decoration increased cellular uptake of the Ce6 loaded liposome in cancer cells by the tumor-targeting and immune escape capacity and produced a satisfactory inhibitory effect on breast cancer. Our study provides a biomimetic strategy the biological properties of Pm to improve the antitumor performance of photodynamic therapy for treating breast cancer.
基于纳米载体的光动力疗法（PDT）已成为癌症治疗中一种很有前途的治疗方法。然而，PDT 的治疗效果受到缺乏特异性、有限的细胞内细胞毒性活性氧（ROS）生成和免疫抑制肿瘤微环境的限制。本文中，开发了一种血小板膜（Pm）修饰和载有氯乙酮（Ce6）的脂质体（Pm/Lps/Ce6），以提高特异性肿瘤靶向能力和抗肿瘤反应。Pm/Lps/Ce6 能够有效地提高 Ce6 的细胞内化。在 660nm 激光照射下，产生足够的 ROS 抑制肿瘤细胞的生长。通过肿瘤靶向和免疫逃逸能力，Pm 的修饰增加了载有 Ce6 的脂质体在癌细胞中的细胞摄取，对乳腺癌产生了令人满意的抑制作用。本研究提供了一种仿生策略，利用 Pm 的生物学特性来提高光动力疗法治疗乳腺癌的抗肿瘤性能。
