自然遗传工程：一种程序性染色体/DNA消除。
Natural genetic engineering: A programmed chromosome/DNA elimination.
作者信息
Kloc Malgorzata, Kubiak Jacek Z, Ghobrial Rafik M
机构信息
The Houston Methodist Research Institute, Houston, TX, USA; The Houston Methodist Hospital, Department of Surgery, Houston, TX, USA; The University of Texas, MD Anderson Cancer Center, Department of Genetics Houston, TX, USA.
Laboratory of Molecular Oncology and Innovative Therapies, Department of Oncology, Military Institute of Medicine, 04-141, Warsaw, Poland; Univ Rennes, UMR 6290, CNRS, Institute of Genetics and Development of Rennes, Dynamics and Mechanics of Epithelia Group, Faculty of Medicine, 35000, Rennes, France.
出版信息
Dev Biol. 2022 Jun;486:15-25. doi: 10.1016/j.ydbio.2022.03.008. Epub 2022 Mar 20.
Typically, all cells of a given organism have the same set of chromosomes. However, there are exceptions to this rule, and in many organisms, the somatic cells and germ cells, various types of somatic cells or organs, or females and males, have different genomes. One of the sources of such differences is chromosome/DNA elimination/chromatin diminution that is a naturally programmed phenomenon. We describe chromosome/DNA elimination in various organisms and present the current hypotheses on its origin, mechanisms, significance, and consequences.
通常情况下，给定生物体的所有细胞都具有相同的染色体组。然而，这条规则也有例外，在许多生物体中，体细胞和生殖细胞、各种类型的体细胞或器官，或者雌性和雄性，具有不同的基因组。这种差异的来源之一是染色体/DNA消除/染色质消减，这是一种自然编程的现象。我们描述了各种生物体中的染色体/DNA消除，并提出了关于其起源、机制、意义和后果的当前假说。
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