Laboratory of Veterinary Microbiology, Department of Veterinary Science, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Veterinary Teaching Hospital, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
J Vet Med Sci. 2022 May 1;84(5):648-652. doi: 10.1292/jvms.22-0010. Epub 2022 Mar 24.
The hepatitis B virus (Hepadnaviridae) induces chronic hepatitis and hepatic cancer in humans. A novel domestic cat hepadnavirus (DCH) was recently identified in several countries, however, the DCH infection status of cats in Japan is unknown. Therefore, we investigated the DCH infection rate of 139 cat samples collected in Japan. We identified one positive blood sample (0.78%) from a 17-year-old female cat with chronically elevated alanine aminotransferase. Phylogenetic analysis demonstrated that the DCH strain identified in this study is genetically different from strains in other countries. Further investigations are required to elucidate the evolution of DCH and the impact of DCH infection on hepatic diseases in domestic cats.
乙型肝炎病毒（Hepadnaviridae）可导致人类慢性肝炎和肝癌。最近在多个国家发现了一种新型的猫属乙型肝炎病毒（DCH），然而，日本猫的 DCH 感染状况尚不清楚。因此，我们调查了日本采集的 139 份猫样本的 DCH 感染率。我们从一只 17 岁的雌性慢性丙氨酸转氨酶升高的猫血液样本中鉴定出了一个阳性样本（0.78%）。系统进化分析表明，本研究中鉴定的 DCH 株与其他国家的株在遗传上不同。需要进一步研究来阐明 DCH 的进化以及 DCH 感染对家猫肝脏疾病的影响。
