Willis G L, Hansky J, Smith G C
Regul Pept. 1986 Aug;15(1):87-98. doi: 10.1016/0167-0115(86)90079-0.
Peripheral (50 mg/ml) or central (50 micrograms/microliter) injections of proglumide were made into Sprague-Dawley rats which displayed satiety-like responses after the peripheral (100 micrograms/kg) or central (50 ng in 1 microliter) administration of cholecystokinin (CCK). The satiety produced by CCK injection into the lateral hypothalamus, area postraema and ventromedial hypothalamus was significantly reversed by proglumide injections into these areas during a 4 h food intake test. Peripheral injection of proglumide after central or peripheral CCK injection did not modify this type of CCK-induced satiety. Central proglumide injection produced a reliable decrease in water intake and this is compatible with previous findings which describe the stimulation of water intake after central gastrin administration. These results suggest that various central and peripheral mechanisms which are involved in the regulation of appetite may function independently as a 'failsafe' system.
向斯普拉格-道利大鼠外周（50毫克/毫升）或中枢（50微克/微升）注射丙谷胺，这些大鼠在接受外周（100微克/千克）或中枢（1微升含50纳克）注射胆囊收缩素（CCK）后会表现出类似饱腹感的反应。在4小时食物摄取试验期间，向外侧下丘脑、最后区和腹内侧下丘脑注射CCK所产生的饱腹感，通过向这些区域注射丙谷胺而得到显著逆转。在中枢或外周注射CCK后进行外周注射丙谷胺，并不会改变这种CCK诱导的饱腹感类型。中枢注射丙谷胺可靠地减少了水的摄取，这与之前描述中枢注射胃泌素后刺激水摄取的研究结果一致。这些结果表明，参与食欲调节的各种中枢和外周机制可能作为一个“故障保护”系统独立发挥作用。
