Collins S, Walker D, Forsyth P, Belbeck L
Life Sci. 1983 May 9;32(19):2223-9. doi: 10.1016/0024-3205(83)90420-4.
Intraperitoneal (IP) administration of the glutaramic acid derivative proglumide inhibited satiety induced by all IP doses of cholecystokinin octapeptide (CCK-OP) in 3-hour food-deprived intact rats. Proglumide did not influence satiety when administered alone and did not inhibit satiety induced by IP glucagon. While proglumide did not inhibit satiety induced by low doses of IP bombesin, it partially and significantly inhibited the satiety effects produced by high doses of this peptide. Since bombesin is a known secretagogue for CCK in several species, these results indicate that while bombesin and CCK act independently to induce satiety, the effect induced by high doses of bombesin is mediated, in part, by the release of endogenous CCK or a structurally related peptide. Furthermore, these results illustrate that proglumide is a specific antagonist of CCK-induced satiety and is, therefore, a potentially useful tool for investigating the physiologic role of this peptide in the control of food intake.
在禁食3小时的完整大鼠中，腹腔注射谷氨酸衍生物丙谷胺可抑制所有腹腔注射剂量的八肽胆囊收缩素（CCK-OP）诱导的饱腹感。单独给药时，丙谷胺不影响饱腹感，也不抑制腹腔注射胰高血糖素诱导的饱腹感。虽然丙谷胺不抑制低剂量腹腔注射蛙皮素诱导的饱腹感，但它能部分且显著地抑制高剂量该肽产生的饱腹感。由于蛙皮素在多个物种中是已知的CCK促分泌素，这些结果表明，虽然蛙皮素和CCK独立发挥作用诱导饱腹感，但高剂量蛙皮素诱导的效应部分是由内源性CCK或结构相关肽的释放介导的。此外，这些结果表明丙谷胺是CCK诱导饱腹感的特异性拮抗剂，因此是研究该肽在控制食物摄入中的生理作用的潜在有用工具。
