发达国家和发展中国家头颈癌的风险因素：来自INHANCE联盟的分析。

Risk factors for head and neck cancer in more and less developed countries: Analysis from the INHANCE consortium.

作者信息

Goyal Neerav, Hennessy Max, Lehman Erik, Lin Wenxue, Agudo Antonio, Ahrens Wolfgang, Boccia Stefania, Brennan Paul, Brenner Hermann, Cadoni Gabriella, Canova Cristina, Chen Chu, Conway David, Curado Maria Paula, Dal Maso Luigino, Daudt Alexander W, Edefonti Valeria, Fabianova Eleonora, Fernandez Leticia, Franceschi Silvia, Garavello Werner, Gillison Maura, Hayes Richard B, Healy Claire, Herrero Rolando, Holcatova Ivana, Kanda Jossy L, Kelsey Karl, Hansen Bo T, Koifman Rosalina, Lagiou Pagona, La Vecchia Carlo, Levi Fabio, Li Guojun, Lissowska Jolanta, Mendoza López Rossana, Luce Danièle, Macfarlane Gary, Mates Dana, Matsuo Keitaro, McClean Michael, Menezes Ana, Menvielle Gwenn, Morgenstern Hal, Moysich Kirsten, Negri Eva, Olshan Andrew F, Pandics Tamas, Polesel Jerry, Purdue Mark, Radoi Loredana, Ramroth Heribert, Richiardi Lorenzo, Schantz Stimson, Schwartz Stephen M, Serraino Diego, Shangina Oxana, Smith Elaine, Sturgis Erich M, Świątkowska Beata, Thomson Peter, Vaughan Thomas L, Vilensky Marta, Winn Deborah M, Wunsch-Filho Victor, Yu Guo-Pei, Zevallos Jose P, Zhang Zuo-Feng, Zheng Tongzhang, Znaor Ariana, Boffetta Paolo, Hashibe Mia, Lee Yuan-Chin A, Muscat Joshua E

机构信息

College of Medicine, The Pennsylvania State University, Hershey, Pennsylvania, USA.

Institut Catala Oncologia, Barcelona, Spain.

出版信息

Oral Dis. 2023 May;29(4):1565-1578. doi: 10.1111/odi.14196. Epub 2022 Apr 8.

DOI:10.1111/odi.14196

PMID:35322907

Abstract

OBJECTIVE

We analyzed the pooled case-control data from the International Head and Neck Cancer Epidemiology (INHANCE) consortium to compare cigarette smoking and alcohol consumption risk factors for head and neck cancer between less developed and more developed countries.

SUBJECTS AND METHODS

The location of each study was categorized as either a less developed or more developed country. We compared the risk of overall head and neck cancer and cancer of specific anatomic subsites associated with cigarette smoking and alcohol consumption. Additionally, age and sex distribution between categories was compared.

RESULTS

The odds ratios for head and neck cancer sites associated with smoking duration differed between less developed and more developed countries. Smoking greater than 20 years conferred a higher risk for oral cavity and laryngeal cancer in more developed countries, whereas the risk was greater for oropharynx and hypopharynx cancer in less developed countries. Alcohol consumed for more than 20 years conferred a higher risk for oropharynx, hypopharynx, and larynx cancer in less developed countries. The proportion of cases that were young (<45 years) or female differed by country type for some HNC subsites.

CONCLUSION

These findings suggest the degree of industrialization and economic development affects the relationship between smoking and alcohol with head and neck cancer.

摘要

目的

我们分析了国际头颈癌流行病学（INHANCE）联盟的汇总病例对照数据，以比较欠发达国家和较发达国家中头颈癌的吸烟和饮酒风险因素。

对象与方法

每项研究的地点被归类为欠发达国家或较发达国家。我们比较了与吸烟和饮酒相关的总体头颈癌以及特定解剖亚部位癌症的风险。此外，还比较了不同类别之间的年龄和性别分布。

结果

欠发达国家和较发达国家中，与吸烟持续时间相关的头颈癌部位的优势比有所不同。在较发达国家，吸烟超过20年使口腔癌和喉癌的风险更高，而在欠发达国家，口咽癌和下咽癌的风险更高。在欠发达国家，饮酒超过20年使口咽癌、下咽癌和喉癌的风险更高。对于某些头颈癌亚部位，年轻（<45岁）或女性病例的比例因国家类型而异。