Medical Oncology Department, Doctor Peset University Hospital, 46017 Valencia, Spain.
Medical Oncology Department, Hospital Center of Wallonie Picardy, 7500 Tournai, Belgium.
Curr Oncol. 2022 Mar 7;29(3):1744-1760. doi: 10.3390/curroncol29030144.
Frailty syndrome is associated with poor outcomes, morbidity and premature mortality. We performed a cross-sectional study to evaluate the presence of frailty syndrome based on Fried’s frailty phenotype in post-menopausal women with breast cancer. We further analyzed the association between frailty syndrome with geriatric assessments and the association with the concentration of gonadotropins LH and FSH, estrogens, androgens and the aromatase activity index in the blood. We enrolled 47 post-menopausal women with localized breast cancer (mean age 66.8 ± 1.3 years (range 52−83)) prior to the starting of adjuvant endocrine therapy. Patients were identified as “non-frail” (robust) or “prefrail/frail” if they fulfilled at least one frailty criteria. In order to determine associations among variables and to control for other variables potentially affecting frailty syndrome (age, comorbidity index and previous chemotherapy treatment), we performed a logistic regression analysis. The receiver operating characteristic curve was performed to assess the sensitivity and specificity of the hormonal concentration to discriminate prefrail/frail versus non-frail individuals. Significant positive associations were observed between the severity of frailty syndrome and estrone, FSH and LH concentrations and the aromatase activity index in the blood (p < 0.05). Further research into the role of hormonal biomarkers should be evaluated in follow-up studies in order to recommend their use as suitable biomarkers of frailty syndrome in breast cancer patients.
衰弱综合征与不良结局、发病率和过早死亡有关。我们进行了一项横断面研究，评估了基于 Fried 衰弱表型的衰弱综合征在绝经后乳腺癌女性中的存在。我们进一步分析了衰弱综合征与老年评估之间的关系，以及与血液中促性腺激素 LH 和 FSH、雌激素、雄激素和芳香化酶活性指数浓度之间的关系。我们招募了 47 名接受辅助内分泌治疗前局部乳腺癌的绝经后女性（平均年龄 66.8 ± 1.3 岁（范围 52-83））。如果患者符合至少一项衰弱标准，则将其确定为“非衰弱（健壮）”或“衰弱前/衰弱”。为了确定变量之间的关联，并控制可能影响衰弱综合征的其他变量（年龄、合并症指数和以前的化疗治疗），我们进行了逻辑回归分析。为了评估激素浓度区分衰弱前/衰弱与非衰弱个体的敏感性和特异性，我们进行了Receiver Operating Characteristic 曲线分析。衰弱综合征的严重程度与血液中雌酮、FSH 和 LH 浓度以及芳香化酶活性指数呈显著正相关（p < 0.05）。应该在后续研究中进一步研究激素生物标志物的作用，以推荐将其作为乳腺癌患者衰弱综合征的合适生物标志物。
