Graduate School, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Nursing Department, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.
Support Care Cancer. 2022 Apr;30(4):2993-3006. doi: 10.1007/s00520-021-06641-8. Epub 2021 Oct 25.
Coexistence of frailty and breast cancer (BC) is related to a higher risk of hospitalization, mortality, and falls. Given the potential reversibility of frailty, investigating its epidemiology in BC is of great importance. However, estimates of the prevalence of frailty in BC patients vary considerably. We synthesized the existing body of literature on the prevalence of frailty among BC patients.
We searched English databases (Cochrane Library, PubMed, Medline, CINAHL, Embase, Scopus, and Web of Science) and Chinese databases (CNKI, WanFang, CBM, and VIP database) from the inception to April 15, 2021, and collected observational studies about the prevalence of frailty among BC patients. The robustness of the pooled estimates was validated by analysis of different subgroups, meta-regression, and sensitivity. All data were analyzed using Stata 15.1.
In total, 4645 articles were screened and data from 24 studies involving 13,510 subjects were used in the meta-analysis. The prevalence of frailty among BC patients in individual studies varied from 5 to 71%. The pooled prevalence of frailty was 43% (95% confidence intervals (CI): 36% to 50%, I = 98.4%, P < 0.05). Subgroup analyses revealed that the therapeutic method, frailty scales, age, frailty stage, regions, publication years, and study quality were associated with the prevalence of frailty among BC patients.
The prevalence of frailty among BC patients was relatively high, and the conditions of BC treatment can increase the risk of frailty. Understanding the effects of frailty on BC, especially in elderly patients, can provide the healthcare personnel with the theoretical basis for patients' management and treatment.
虚弱和乳腺癌（BC）共存与住院风险、死亡率和跌倒风险增加有关。鉴于虚弱具有潜在的可逆转性，研究 BC 患者的虚弱流行病学具有重要意义。然而，BC 患者虚弱的患病率估计差异很大。我们综合了现有关于 BC 患者虚弱患病率的文献。
我们从建库到 2021 年 4 月 15 日，检索了英文数据库（Cochrane Library、PubMed、Medline、CINAHL、Embase、Scopus 和 Web of Science）和中文数据库（CNKI、万方、CBM 和 VIP 数据库），收集了关于 BC 患者虚弱患病率的观察性研究。通过分析不同亚组、meta 回归和敏感性分析来验证汇总估计值的稳健性。所有数据均使用 Stata 15.1 进行分析。
共筛选出 4645 篇文章，纳入了 24 项研究，共 13510 名受试者的数据用于荟萃分析。个体研究中 BC 患者虚弱的患病率从 5%到 71%不等。BC 患者虚弱的总患病率为 43%（95%置信区间：36%至 50%，I=98.4%，P<0.05）。亚组分析表明，治疗方法、虚弱量表、年龄、虚弱阶段、地区、发表年份和研究质量与 BC 患者虚弱的患病率相关。
BC 患者的虚弱患病率相对较高，BC 的治疗情况会增加虚弱的风险。了解虚弱对 BC 的影响，尤其是在老年患者中，可以为医疗保健人员提供患者管理和治疗的理论基础。
