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季铵化壳聚糖-聚乙烯醇复合纳米纤维膜的静电纺丝：工艺优化及抗菌效果

Electrospinning of Quaternized Chitosan-Poly(vinyl alcohol) Composite Nanofiber Membrane: Processing Optimization and Antibacterial Efficacy.

作者信息

Wu Jheng-Yu, Wang Chi-Yun, Chen Kuei-Hsiang, Lai You-Ren, Chiu Chen-Yaw, Lee Hung-Che, Chang Yu-Kaung

机构信息

Department of Chemical Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan.

International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, New Taipei City 243303, Taiwan.

出版信息

Membranes (Basel). 2022 Mar 17;12(3):332. doi: 10.3390/membranes12030332.

DOI:10.3390/membranes12030332
PMID:35323807
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8953842/
Abstract

-(2-hydroxy) propyl-3-trimethylammonium chitosan chloride (HTCC) is a type of quaternary ammonium chitosan derivative with an antibacterial activity superior to the pristine chitosan, but its electrospinnability is limited. In this study, polyvinyl alcohol (PVA) was blended with HTCC to improve the electrospinnability of nanofibers. The electrospinning of PVA-HTCC nanofiber membranes was optimized in terms of structural stability and antimicrobial performance. Based on scanning electron microscopic analysis, the morphology and diameter of the produced nanofibers were influenced by the applied voltage, flow rate of the feed solution, and weight ratio of the polymer blend. An increase in the HTCC content decreased the average nanofiber diameter. The maximum water solubility of the PVA-HTCC nanofibers reached the maximum value of 70.92% at 12 h and 25 °C. The antibacterial activity of PVA-HTCC nanofiber membranes against was ~90%, which is significantly higher than that of PVA-chitosan nanofiber membrane. Moreover, the antibacterial efficiency of PVA-HTCC nanofiber membranes remained unaffected after 5 cycles of antibacterial treatment. The good antibacterial performance and biocompatibility of PVA-HTCC nanofiber membrane makes them attractive for biomedical and biochemical applications that necessitate sterile conditions.

摘要

氯化-（2-羟基）丙基-3-三甲基铵壳聚糖（HTCC）是一种季铵化壳聚糖衍生物，其抗菌活性优于原始壳聚糖，但其可电纺性有限。在本研究中，将聚乙烯醇（PVA）与HTCC共混以提高纳米纤维的可电纺性。从结构稳定性和抗菌性能方面对PVA-HTCC纳米纤维膜的电纺过程进行了优化。基于扫描电子显微镜分析，所制备纳米纤维的形态和直径受施加电压、进料溶液流速以及聚合物共混物重量比的影响。HTCC含量的增加会降低纳米纤维的平均直径。PVA-HTCC纳米纤维在12小时和25℃下的最大水溶性达到70.92%的最大值。PVA-HTCC纳米纤维膜对[此处原文缺失具体菌种]的抗菌活性约为90%，显著高于PVA-壳聚糖纳米纤维膜。此外，经过5次抗菌处理后，PVA-HTCC纳米纤维膜的抗菌效率仍未受影响。PVA-HTCC纳米纤维膜良好的抗菌性能和生物相容性使其在需要无菌条件的生物医学和生物化学应用中具有吸引力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/22310d742e34/membranes-12-00332-g011a.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/f7fb53dded24/membranes-12-00332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/3ec29fd97cf2/membranes-12-00332-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/6556b1353ec9/membranes-12-00332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/ba02d38a2342/membranes-12-00332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/6fd7ddd8f64d/membranes-12-00332-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/774ada5b3dc2/membranes-12-00332-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/da9fbf9d0566/membranes-12-00332-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/eee5cb43f464/membranes-12-00332-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/22310d742e34/membranes-12-00332-g011a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/676ea76b8476/membranes-12-00332-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/35a296444b0a/membranes-12-00332-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/f7fb53dded24/membranes-12-00332-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/3ec29fd97cf2/membranes-12-00332-g004a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/6556b1353ec9/membranes-12-00332-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/ba02d38a2342/membranes-12-00332-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/6fd7ddd8f64d/membranes-12-00332-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/774ada5b3dc2/membranes-12-00332-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/da9fbf9d0566/membranes-12-00332-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/eee5cb43f464/membranes-12-00332-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fb2/8953842/22310d742e34/membranes-12-00332-g011a.jpg

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