Sirinek K R, O'Dorisio T M, Hill D, McFee A S
Surgery. 1986 Oct;100(4):781-7.
The role of glucose-dependent insulinotropic polypeptide (GIP) in the hyperinsulinism of morbid obesity and its correction after gastric bypass was studied in 12 morbidly obese (150 +/- 15 kg) patients. After oral glucose, significant increases in serum glucose, insulin, and GIP levels occurred both before and after gastric bypass. Compared with preoperative values, fasting concentrations and integrated incremental areas for glucose, insulin, and GIP were decreased after a 25% weight loss after gastric bypass. The hyperinsulinism of morbid obesity and its amelioration after gastric bypass may be caused by markedly elevated levels of GIP before surgery and its reduced release after bypass. Reduced release of GIP after gastric bypass may partly occur because of exclusion of ingested glucose from contact with the mucosa of the duodenum and proximal jejunum, sites with the highest concentration of GIP.
在12例病态肥胖（体重150±15千克）患者中，研究了葡萄糖依赖性促胰岛素多肽（GIP）在病态肥胖高胰岛素血症中的作用及其在胃旁路术后的变化。口服葡萄糖后，胃旁路术前和术后血清葡萄糖、胰岛素和GIP水平均显著升高。与术前值相比，胃旁路术后体重减轻25%后，葡萄糖、胰岛素和GIP的空腹浓度及累积增量面积均降低。病态肥胖的高胰岛素血症及其在胃旁路术后的改善可能是由于术前GIP水平显著升高以及术后其释放减少所致。胃旁路术后GIP释放减少可能部分是因为摄入的葡萄糖无法与十二指肠和空肠近端黏膜接触，而这些部位是GIP浓度最高的地方。
