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吡洛芬(rengasil)联合维持剂量皮质类固醇治疗类风湿关节炎的双盲多中心试验研究

[Study of pirprofen (rengasil) combined with maintenance doses of corticosteroids in rheumatoid arthritis in a double-blind multicenter trial].

作者信息

Trofimova T M, Alekberova Z S, Pokryshkin V I, Kobaladze S G, Taletene I P

出版信息

Ter Arkh. 1986;58(7):95-7.

PMID:3532404
Abstract

A study of pirprofen (rengasil) combined with small doses of corticosteroids in 93 patients with rheumatoid arthritis during a double blind multicentre testing showed good and satisfactory therapeutic results in 60%. A decrease in morning rigidity, pains in the joints especially at night, the joint index and in the number of inflammed joints was noted. Rengasil tolerance was good, side effects were few. The new nonsteroid antiinflammatory drug rengasil combined with maintenance doses of corticosteroids can be recommended for a prolonged treatment of patients with rheumatoid arthritis.

摘要

一项针对93例类风湿性关节炎患者的双盲多中心试验,研究了吡洛芬(rengasil)与小剂量皮质类固醇联合使用的情况,结果显示60%的患者治疗效果良好且令人满意。观察到晨僵减轻、关节疼痛尤其是夜间疼痛、关节指数以及炎症关节数量均有所减少。rengasil耐受性良好,副作用较少。新型非甾体抗炎药rengasil与维持剂量的皮质类固醇联合使用,可推荐用于类风湿性关节炎患者的长期治疗。

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