Retina and Vitreous Services, LV Prasad Eye Institute, Mithu Tulsi Chanrai Campus, Bhubaneswar, Odisha, India.
Srimati Kanuri Santhamma Centre for Vitreoretinal Diseases, Cuttack, Odisha, India.
Indian J Ophthalmol. 2022 Apr;70(4):1270-1277. doi: 10.4103/ijo.IJO_1484_21.
To analyze the weekly rate of retinal vascular growth in treatment-naïve babies with various stages of retinopathy of prematurity (ROP) and validate if this could be a predictor of treatment need.
Retrospective review of medical charts and retinal images of babies with various stages of ROP. The images were enhanced using red-green image enhancement software. Using the length of the horizontal disc diameter (DD) of each eye, the vessel growth was measured from the disc margin up to the vessel tip in fixed quadrants. The rate of vessel growth was the ratio of vessel length to the number of weeks it took to reach this length. The babies were divided into treatment warranting ROP (group 1), low-risk pre-threshold (type II) ROP (group 2,), and no-ROP (group 3) for analysis. The "no-ROP" group acted as normal control. Group 1 was further subdivided into 1A (threshold ROP), IB (aggressive posterior ROP), 1C (hybrid ROP), and ID (high-risk pre-threshold ROP).
Out of 436 eyes, groups 1, 2, and 3 had 238, 108, and 90 eyes, respectively. The mean rate of vascular outgrowth along with 95% confidence interval (CI) was 0.490 [0.487,0.520], 0.612 [0.599, 0.638], and 0.719 [0.703, 0.740] DD/week, respectively, for babies with "treatment warranting," "low risk pre-threshold" and "no ROP" groups, respectively. In our estimate, more than 80% of eyes with a vessel growth rate of 0.54 DD/week or less required treatment.
A rate of retinal vascular growth less than 0.54 DD/week can be used to determine treatment requirements in babies with ROP.
分析不同分期早产儿视网膜病变（ROP）患儿未经治疗时每周视网膜血管生长速度，并验证其是否可作为治疗需求的预测指标。
回顾性分析不同分期 ROP 患儿的病历和视网膜图像。使用红绿图像增强软件增强图像。以每只眼的水平视盘直径（DD）长度为基础，从视盘边缘到血管末端在固定象限测量血管生长长度。血管生长速度为血管长度与达到该长度所需的周数之比。将患儿分为治疗需要 ROP（1 组）、低危阈值前（Ⅱ型）ROP（2 组）和无 ROP（3 组）进行分析。“无 ROP”组作为正常对照组。1 组进一步分为 1A（阈值 ROP）、1B（进展性后部 ROP）、1C（混合性 ROP）和 1D（高危阈值前 ROP）。
在 436 只眼中，1、2 和 3 组分别有 238、108 和 90 只眼。血管生长的平均速度及 95%置信区间（CI）分别为 0.490[0.487,0.520]、0.612[0.599,0.638]和 0.719[0.703,0.740]DD/周，分别为“治疗需要”、“低危阈值前”和“无 ROP”组的患儿。我们的估计表明，80%以上的血管生长速度低于 0.54DD/周的眼需要治疗。
视网膜血管生长速度小于 0.54DD/周可用于确定 ROP 患儿的治疗需求。
