Laboratory of Physiology and Toxicology of Reproduction, Institute of Zoology and Biomedical Research, Jagiellonian University in Krakow, 30-387 Krakow, Poland.
Department of Animal Anatomy and Physiology, Faculty of Biology and Biotechnology, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland.
Cells. 2022 Mar 10;11(6):957. doi: 10.3390/cells11060957.
The corpus luteum is a small gland of great importance because its proper functioning determines not only the appropriate course of the estrous/menstrual cycle and embryo implantation, but also the subsequent maintenance of pregnancy. Among the well-known regulators of luteal tissue functions, increasing attention is focused on the role of neuropeptides and adipose tissue hormones-adipokines. Growing evidence points to the expression of these factors in the corpus luteum of women and different animal species, and their involvement in corpus luteum formation, endocrine function, angiogenesis, cells proliferation, apoptosis, and finally, regression. In the present review, we summarize the current knowledge about the expression and role of adipokines, such as adiponectin, leptin, apelin, vaspin, visfatin, chemerin, and neuropeptides like ghrelin, orexins, kisspeptin, and phoenixin in the physiological regulation of the corpus luteum function, as well as their potential involvement in pathologies affecting the luteal cells that disrupt the estrous cycle.
黄体是一种非常重要的小腺体，因为它的正常功能不仅决定了发情/月经周期和胚胎着床的适当过程，还决定了随后的妊娠维持。在黄体组织功能的众多知名调节剂中，人们越来越关注神经肽和脂肪组织激素-脂肪因子的作用。越来越多的证据表明，这些因子在女性和不同动物物种的黄体中表达，并参与黄体形成、内分泌功能、血管生成、细胞增殖、细胞凋亡，最终导致黄体退化。在本综述中，我们总结了有关脂肪因子（如脂联素、瘦素、apelin、vaspin、visfatin、chemerin）和神经肽（如 ghrelin、orexins、kisspeptin、phoenixin）在黄体功能的生理调节中的表达和作用的最新知识，以及它们在影响扰乱发情周期的黄体细胞的病理中的潜在作用。
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