内毒素相关女性生育力下降的潜在机制和治疗策略。
Potential mechanisms and therapeutic strategies for LPS-associated female fertility decline.
机构信息
The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu, China.
Department of Obstetrics and Gynecology, Key Laboratory for Gynecologic Oncology Gansu Province, The First Hospital of Lanzhou University, No.1, Donggangxi Rd, Chengguan District, Lanzhou, 730000, China.
出版信息
J Assist Reprod Genet. 2024 Oct;41(10):2739-2758. doi: 10.1007/s10815-024-03226-2. Epub 2024 Aug 21.
As a major component of the outer membrane of Gram-negative bacteria, lipopolysaccharide (LPS) can be recognized by toll-like receptors (TLRs) and induce inflammation through MyD88 or the TIR domain-containing adapter-inducing interferon-β (TRIF) pathway. Previous studies have found that LPS-associated inflammatory/immune challenges were associated with ovarian dysfunction and reduced female fertility. However, the etiology and pathogenesis of female fertility decline associated with LPS are currently complex and multifaceted. In this review, PubMed was used to search for references on LPS and fertility decline so as to elucidate the potential mechanisms of LPS-associated female fertility decline and summarize therapeutic strategies that may improve LPS-associated fertility decline.
作为革兰氏阴性菌外膜的主要成分，脂多糖 (LPS) 可以被 Toll 样受体 (TLRs) 识别，并通过 MyD88 或 TIR 结构域包含衔接子诱导干扰素-β (TRIF) 途径引发炎症。先前的研究发现，与 LPS 相关的炎症/免疫挑战与卵巢功能障碍和女性生育能力下降有关。然而，目前与 LPS 相关的女性生育力下降的病因和发病机制复杂且多方面。在本综述中，我们使用 PubMed 搜索了关于 LPS 和生育力下降的参考文献，以阐明 LPS 相关女性生育力下降的潜在机制，并总结可能改善 LPS 相关生育力下降的治疗策略。
Zotero 插件