Ear Science Institute Australia, Subiaco, WA 6008, Australia.
Ear Sciences Centre, School of Surgery, University of Western Australia, Crawley, WA 6009, Australia.
Cells. 2022 Mar 16;11(6):1007. doi: 10.3390/cells11061007.
In 2020, 55 million people worldwide were living with dementia, and this number is projected to reach 139 million in 2050. However, approximately 75% of people living with dementia have not received a formal diagnosis. Hence, they do not have access to treatment and care. Without effective treatment in the foreseeable future, it is essential to focus on modifiable risk factors and early intervention. Central auditory processing is impaired in people diagnosed with Alzheimer's disease (AD) and its preclinical stages and may manifest many years before clinical diagnosis. This study systematically reviewed central auditory processing function in AD and its preclinical stages using behavioural central auditory processing tests. Eleven studies met the full inclusion criteria, and seven were included in the meta-analyses. The results revealed that those with mild cognitive impairment perform significantly worse than healthy controls within channel adaptive tests of temporal response (ATTR), time-compressed speech test (TCS), Dichotic Digits Test (DDT), Dichotic Sentence Identification (DSI), Speech in Noise (SPIN), and Synthetic Sentence Identification-Ipsilateral Competing Message (SSI-ICM) central auditory processing tests. In addition, this analysis indicates that participants with AD performed significantly worse than healthy controls in DDT, DSI, and SSI-ICM tasks. Clinical implications are discussed in detail.
2020 年，全球有 5500 万人患有痴呆症，预计到 2050 年这一数字将达到 1.39 亿。然而，大约 75%的痴呆症患者尚未得到正式诊断。因此，他们无法获得治疗和护理。在可预见的未来，如果没有有效的治疗方法，那么关注可改变的风险因素和早期干预就显得尤为重要。在被诊断患有阿尔茨海默病（AD）及其临床前阶段的人群中，中枢听觉处理受损，并且可能在临床诊断前多年就已经出现。本研究使用行为中枢听觉处理测试系统地综述了 AD 及其临床前阶段的中枢听觉处理功能。符合全部纳入标准的研究有 11 项，其中 7 项纳入荟萃分析。结果表明，轻度认知障碍患者在时间响应通道自适应测试（ATTR）、时间压缩语音测试（TCS）、双耳分听测试（DDT）、双耳句子识别测试（DSI）、噪声下言语测试（SPIN）和合成句子识别同侧竞争信息测试（SSI-ICM）的中枢听觉处理测试中表现明显差于健康对照组。此外，该分析表明 AD 患者在 DDT、DSI 和 SSI-ICM 任务中的表现明显差于健康对照组。详细讨论了临床意义。
