Moreira Helena, Szyjka Anna, Grzesik Justyna, Pelc Katarzyna, Żuk Magdalena, Kulma Anna, Emhemmed Fathi, Muller Christian D, Gąsiorowski Kazimierz, Barg Ewa
Department of Basic Medical Sciences, Faculty of Pharmacy, Wroclaw Medical University, 50-367 Wroclaw, Poland.
Department of Genetic Biochemistry, Faculty of Biotechnology, University of Wroclaw, 50-137 Wroclaw, Poland.
Cancers (Basel). 2022 Mar 8;14(6):1372. doi: 10.3390/cancers14061372.
Metastatic colorectal cancer (CRC) remains a hard-to-cure neoplasm worldwide. Its curability declines with successive lines of treatment due to the development of various cancer resistance mechanisms and the presence of colorectal cancer stem cells (CSCs). Celastrol and resveratrol are very promising phytochemicals for colon cancer therapy, owing to their pleiotropic activity that enables them to interact with various biological targets. In the present study, the anticancer activities of both compounds were investigated in metastatic colon cancer cells (LoVo cells) and cancer stem-like cells (LoVo/DX). We showed that celastrol is a very potent anti-tumor compound against metastatic colon cancer, capable of attenuating CSC-like cells at the molecular and cellular levels. In contrast, resveratrol has a much greater effect on colon cancer cells that are expressing standard sensitivity to anticancer drugs, than on CSC-like cells. In addition, both polyphenols have different influences on the expression of genes, which seems to be at least partly related to their anti-tumor activity.
转移性结直肠癌（CRC）在全球范围内仍然是一种难以治愈的肿瘤。由于各种癌症耐药机制的发展以及结直肠癌干细胞（CSCs）的存在，其治愈率随着后续治疗线数的增加而下降。雷公藤红素和白藜芦醇是用于结肠癌治疗的非常有前景的植物化学物质，因为它们具有多效性活性，能够与各种生物靶点相互作用。在本研究中，研究了这两种化合物在转移性结肠癌细胞（LoVo细胞）和癌症干细胞样细胞（LoVo/DX）中的抗癌活性。我们表明，雷公藤红素是一种针对转移性结肠癌的非常有效的抗肿瘤化合物，能够在分子和细胞水平上减弱CSC样细胞。相比之下，白藜芦醇对表达对抗癌药物具有标准敏感性的结肠癌细胞的影响比对CSC样细胞的影响大得多。此外，这两种多酚对基因表达有不同的影响，这似乎至少部分与其抗肿瘤活性有关。
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