线粒体DNA对肿瘤相关巨噬细胞极化及免疫的影响
Mitochondrial DNA on Tumor-Associated Macrophages Polarization and Immunity.
作者信息
Guo Yaxin, Tsai Hsiang-I, Zhang Lirong, Zhu Haitao
机构信息
Department of Medical Imaging, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
Laboratory of Radiology, The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China.
出版信息
Cancers (Basel). 2022 Mar 11;14(6):1452. doi: 10.3390/cancers14061452.
As the richest immune cells in most tumor microenvironments (TMEs), tumor-associated macrophages (TAMs) play an important role in tumor development and treatment sensitivity. The phenotypes and functions of TAMs vary according to their sources and tumor progression. Different TAM phenotypes display distinct behaviors in terms of tumor immunity and are regulated by intracellular and exogenous molecules. Additionally, dysfunctional and oxidatively stressed mitochondrial-derived mitochondrial DNA (mtDNA) plays an important role in remodeling the phenotypes and functions of TAMs. This article reviews the interactions between mtDNA and TAMs in the TME and further discusses the influence of their performance on tumor genesis and development.
作为大多数肿瘤微环境（TME）中最丰富的免疫细胞，肿瘤相关巨噬细胞（TAM）在肿瘤发展和治疗敏感性中发挥着重要作用。TAM的表型和功能因其来源和肿瘤进展而异。不同的TAM表型在肿瘤免疫方面表现出不同的行为，并受细胞内和外源性分子的调节。此外，功能失调和氧化应激的线粒体衍生线粒体DNA（mtDNA）在重塑TAM的表型和功能方面发挥着重要作用。本文综述了TME中mtDNA与TAM之间的相互作用，并进一步讨论了它们的表现对肿瘤发生和发展的影响。
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