Li Lunxu, Tian Yu
Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
Department of General Surgery, Shengjing Hospital of China Medical University, Shenyang, China.
Biomed Pharmacother. 2023 May;161:114504. doi: 10.1016/j.biopha.2023.114504. Epub 2023 Mar 14.
Macrophages are potent immune effector cells in innate immunity and exert dual-effects in the tumor microenvironment (TME). Tumor-associated macrophages (TAMs) make up a significant portion of TME immune cells. Similar to M1/M2 macrophages, TAMs are also highly plastic, and their functions are regulated by cytokines, chemokines and other factors in the TME. The metabolic changes in TAMs are significantly associated with polarization towards a protumour or antitumour phenotype. The metabolites generated via TAM metabolic reprogramming in turn promote tumor progression and immune tolerance. In this review, we explore the metabolic reprogramming of TAMs in terms of energy, amino acid and fatty acid metabolism and the potential roles of these changes in immune suppression.
巨噬细胞是固有免疫中强大的免疫效应细胞，在肿瘤微环境（TME）中发挥双重作用。肿瘤相关巨噬细胞（TAM）构成了TME免疫细胞的重要组成部分。与M1/M2巨噬细胞类似，TAM也具有高度可塑性，其功能受TME中的细胞因子、趋化因子和其他因素调节。TAM的代谢变化与向促肿瘤或抗肿瘤表型的极化显著相关。通过TAM代谢重编程产生的代谢产物反过来促进肿瘤进展和免疫耐受。在本综述中，我们从能量、氨基酸和脂肪酸代谢方面探讨TAM的代谢重编程以及这些变化在免疫抑制中的潜在作用。
