Núcleo de Pesquisa em Oncologia, Federal University of Pará, Belém 66073-000, Brazil.
Laboratório de Genética Humana e Médica, Federal University of Pará, Belém 66073-000, Brazil.
Genes (Basel). 2022 Mar 11;13(3):499. doi: 10.3390/genes13030499.
Genetic variations in have been associated with different pathologies in global literature, but there are no data regarding this gene in Native American populations. The Amazonian Native American populations have lower genetic diversity and are more different from other continental groups. We investigated 18 genetic variants in the gene in Amazonian indigenous and compared our results with the ones found in global populations, which were publicly available in the 1000 Genomes Project, gnmAD and ABraOM databases. The results demonstrated that the variants of the , especially rs17156844, rs550369696, rs61741659 and rs2877, have a significantly higher frequency in Amerindian populations in comparison with other continental populations. These data outline the singular genetic profile of the Native American population from the Brazilian Amazon region.
在全球文献中， 基因的遗传变异与不同的病理学有关，但在美洲原住民群体中，没有关于该基因的数据。亚马逊地区的美洲原住民群体遗传多样性较低，与其他大陆群体的差异更大。我们调查了 18 个 基因中的遗传变异，并将我们的结果与全球人群中的结果进行了比较，这些结果可在 1000 基因组计划、gnmAD 和 ABraOM 数据库中公开获得。结果表明，特别是 rs17156844、rs550369696、rs61741659 和 rs2877 等 基因的变体在美洲印第安人群体中的频率明显高于其他大陆群体。这些数据描绘了巴西亚马逊地区美洲原住民群体独特的遗传特征。
