BoRdeaux Institute of Oncology (BRIC), UMR1312, INSERM, University of Bordeaux, 146 Rue Leo Saignat, 33076 Bordeaux, France.
Medical Genetics Unit, Faculty of Medicine, Saint Joseph University, Beirut 1104 2020, Lebanon.
Genes (Basel). 2022 Mar 18;13(3):539. doi: 10.3390/genes13030539.
Telomeric Repeat-containing RNA (TERRA) are long non-coding RNAs transcribed from telomeric DNA sequences from multiple chromosome ends. Major research efforts have been made to understand TERRA roles and functions in several physiological and pathological processes. We summarize herein available data regarding TERRA's roles in human cells and we report the first investigation in cutaneous T-cells lymphomas (CTCL) using real-time PCR. Among the TERRA analysed, our data suggest a particular role for TERRA 16p downregulation and TERRA 11q upregulation in CTCL lymphomagenesis.
端粒重复 RNA（TERRA）是从多个染色体末端的端粒 DNA 序列转录而来的长非编码 RNA。人们已经做出了大量努力来了解 TERRA 在多种生理和病理过程中的作用和功能。我们在此总结了有关 TERRA 在人类细胞中的作用的现有数据，并报告了使用实时 PCR 在皮肤 T 细胞淋巴瘤（CTCL）中进行的首次研究。在所分析的 TERRA 中，我们的数据表明 TERRA 16p 下调和 TERRA 11q 上调在 CTCL 淋巴瘤发生中具有特殊作用。
