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端粒重复 RNA (TERRA)：文献综述及皮肤 T 细胞淋巴瘤的初步评估。

Telomeric Repeat-Containing RNA (TERRA): A Review of the Literature and First Assessment in Cutaneous T-Cell Lymphomas.

机构信息

BoRdeaux Institute of Oncology (BRIC), UMR1312, INSERM, University of Bordeaux, 146 Rue Leo Saignat, 33076 Bordeaux, France.

Medical Genetics Unit, Faculty of Medicine, Saint Joseph University, Beirut 1104 2020, Lebanon.

出版信息

Genes (Basel). 2022 Mar 18;13(3):539. doi: 10.3390/genes13030539.

DOI:10.3390/genes13030539
PMID:35328092
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8953746/
Abstract

Telomeric Repeat-containing RNA (TERRA) are long non-coding RNAs transcribed from telomeric DNA sequences from multiple chromosome ends. Major research efforts have been made to understand TERRA roles and functions in several physiological and pathological processes. We summarize herein available data regarding TERRA's roles in human cells and we report the first investigation in cutaneous T-cells lymphomas (CTCL) using real-time PCR. Among the TERRA analysed, our data suggest a particular role for TERRA 16p downregulation and TERRA 11q upregulation in CTCL lymphomagenesis.

摘要

端粒重复 RNA（TERRA）是从多个染色体末端的端粒 DNA 序列转录而来的长非编码 RNA。人们已经做出了大量努力来了解 TERRA 在多种生理和病理过程中的作用和功能。我们在此总结了有关 TERRA 在人类细胞中的作用的现有数据，并报告了使用实时 PCR 在皮肤 T 细胞淋巴瘤（CTCL）中进行的首次研究。在所分析的 TERRA 中，我们的数据表明 TERRA 16p 下调和 TERRA 11q 上调在 CTCL 淋巴瘤发生中具有特殊作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/8953746/33284912eb31/genes-13-00539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/8953746/e8b64c83b968/genes-13-00539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/8953746/5ce360e3d65f/genes-13-00539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/8953746/814c5793bab2/genes-13-00539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/8953746/33284912eb31/genes-13-00539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/8953746/e8b64c83b968/genes-13-00539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/8953746/5ce360e3d65f/genes-13-00539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/8953746/814c5793bab2/genes-13-00539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8c4/8953746/33284912eb31/genes-13-00539-g004.jpg

相似文献

[1]
Telomeric Repeat-Containing RNA (TERRA): A Review of the Literature and First Assessment in Cutaneous T-Cell Lymphomas.

Genes (Basel). 2022-3-18

[2]
Telomeric repeat-containing RNA TERRA: a noncoding RNA connecting telomere biology to genome integrity.

Front Genet. 2015-4-14

[3]
TERRA and Telomere Maintenance in the Yeast .

Genes (Basel). 2023-2-28

[4]
Telomeric Chromatin and TERRA.

J Mol Biol. 2020-7-10

[5]
Noncoding telomeric repeat-containing RNA inhibits the progression of hepatocellular carcinoma by regulating telomerase-mediated telomere length.

Cancer Sci. 2020-7-1

[6]
Genomic origin and nuclear localization of TERRA telomeric repeat-containing RNA: from Darkness to Dawn.

FEBS J. 2017-12-29

[7]
Telomeric RNA (TERRA) increases in response to spaceflight and high-altitude climbing.

Commun Biol. 2024-6-11

[8]
TERRA and the state of the telomere.

Nat Struct Mol Biol. 2015-11

[9]
Generation of Cancer Cell Clones to Visualize Telomeric Repeat-containing RNA TERRA Expressed from a Single Telomere in Living Cells.

J Vis Exp. 2019-1-17

[10]
Human Endometrial Carcinogenesis Is Associated with Significant Reduction in Long Non-Coding RNA, TERRA.

Int J Mol Sci. 2020-11-18

引用本文的文献

[1]
LncRNA TERRA in hybrid with DNA is a relevant biomarker for monitoring patients with meningioma.

Sci Rep. 2025-3-15

[2]
Epigenetic Regulatory Processes Involved in the Establishment and Maintenance of Skin Homeostasis-The Role of Microbiota.

Int J Mol Sci. 2025-1-7

[3]
Non-coding RNAs in the spotlight of the pathogenesis, diagnosis, and therapy of cutaneous T cell lymphoma.

Cell Death Discov. 2024-9-10

[4]
Telomere transcripts act as tumor suppressor and are associated with favorable prognosis in colorectal cancer with low proliferating cell nuclear antigen expression.

Cell Oncol (Dordr). 2025-2

[5]
The role of LncRNA LBX2-AS1 in cancers: functions, mechanisms and potential clinical utility.

Clin Transl Oncol. 2023-2

[6]
TElomeric repeat-containing RNA (TERRA): Physiological functions and relevance in cancer.

Front Oncol. 2022-8-2

本文引用的文献

[1]
Targeting Epigenetic Modifiers Can Reduce the Clonogenic Capacities of Sézary Cells.

Front Oncol. 2021-10-26

[2]
Telomeres and Cancer: Resolving the Paradox.

Annu Rev Cancer Biol. 2021-3

[3]
The makings of TERRA R-loops at chromosome ends.

Cell Cycle. 2021-9

[4]
BRCA1 binds TERRA RNA and suppresses R-Loop-based telomeric DNA damage.

Nat Commun. 2021-6-10

[5]
Epigenetic Characteristics of Human Subtelomeres Vary in Cells Utilizing the Alternative Lengthening of Telomeres (ALT) Pathway.

Life (Basel). 2021-3-26

[6]
TERRA: A Novel Biomarker of Embryo Quality and Art Outcome.

Genes (Basel). 2021-3-25

[7]
Exploring hTERT promoter methylation in cutaneous T-cell lymphomas.

Mol Oncol. 2022-5

[8]
Importance and Meaning of TERRA Sequences for Aging Mechanisms.

Biochemistry (Mosc). 2020-12

[9]
TERRA Gene Expression in Gastric Cancer: Role of hTERT.

J Gastrointest Cancer. 2021-6

[10]
Diagnosis and treatment of lymphomas in the era of epigenetics.

Blood Rev. 2021-7

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