Wegener Lisa C, Werner Felix, Kleyer Arnd, Simon David, Uder Michael, Janka Rolf, Trattnig Siegfried, Welsch Goetz H, Pachowsky Milena L
Friedrich-Alexander-University Erlangen-Nürnberg (FAU), 91054 Erlangen, Germany.
Johanna-Etienne Hospital, 41462 Neuss, Germany.
Diagnostics (Basel). 2022 Feb 27;12(3):605. doi: 10.3390/diagnostics12030605.
(1) Background: To assess whether clinical outcomes correlate with tissue changes in the intervertebral discs (IVDs) after kyphoplasty as treatment for vertebral fractures, quantitative MRI was applied. (2) Methods: Quantitative T2 mapping acquired in a 3 T MRI scanner of the thoracolumbar spine was performed in 20 patients two years after kyphoplasty. The IVDs adjacent and nonadjacent to the treated vertebrae were divided into six regions of interest (ROI), which were further categorised into inner (ROI 2-5) and outer (ROI 1 and 6) parts of the IVDs, and the T2 values were analysed. T2 values of adjacent discs were correlated with the items of questionnaires evaluating the clinical outcome (i.e., 36-Item Short Form Survey). (3) Results: Lower T2 values in adjacent IVDs correlated with poorer physical outcome two years after kyphoplasty. The inner part of the IVDs adjacent to treated vertebrae showed statistically significant lower T2 values in segments L2/L3 and L3/L4 compared to nonadjacent ones. Patients with lower T2 values showed more pain and physical limitations in everyday life. (4) Conclusions: Quantitative T2 mapping can detect IVD degeneration in patients after kyphoplasty and correlates with the physical outcome. This technique could help to gain better insights into alterations in tissue composition following kyphoplasty and the consequences for the patients' quality of life.
(1) 背景：为评估椎体成形术治疗椎体骨折后临床结果是否与椎间盘（IVD）的组织变化相关，应用了定量MRI。(2) 方法：在椎体成形术后两年，对20例患者进行了在3T MRI扫描仪上采集的胸腰椎定量T2成像。将治疗椎体相邻和不相邻的IVD分为六个感兴趣区域（ROI），这些区域进一步分为IVD的内部（ROI 2 - 5）和外部（ROI 1和6）部分，并分析T2值。相邻椎间盘的T2值与评估临床结果的问卷项目（即36项简短问卷调查）相关。(3) 结果：椎体成形术后两年，相邻IVD较低的T2值与较差的身体状况相关。与不相邻的相比，治疗椎体相邻IVD的内部在L2/L3和L3/L4节段显示出统计学上显著更低的T2值。T2值较低的患者在日常生活中疼痛更多且身体受限更多。(4) 结论：定量T2成像可检测椎体成形术后患者的IVD退变，并与身体状况相关。该技术有助于更好地了解椎体成形术后组织成分的改变及其对患者生活质量的影响。
