Georgiadou Petroula, Sokou Rozeta, Tsantes Andreas G, Parastatidou Stavroula, Konstantinidi Aikaterini, Houhoula Dimitra, Kokoris Styliani, Iacovidou Nicoletta, Tsantes Argirios E
Neonatal Intensive Care Unit, "Agios Panteleimon" General Hospital of Nikea, 18454 Piraeus, Greece.
Laboratory of Haematology and Blood Bank Unit, "Attiko" Hospital, School of Medicine, National and Kapodistrian University of Athens, 12462 Athens, Greece.
Diagnostics (Basel). 2022 Mar 8;12(3):658. doi: 10.3390/diagnostics12030658.
The non-activated thromboelastometry (NATEM) assay is a point-of-care assay that can provide a comprehensive insight into the actual hemostatic mechanism. However, there are very limited data about its use in clinical practice. The aim of this study was to systematically review the literature for any data regarding the use of NATEM in several clinical settings. A systematic review of PubMed and Scopus databases was conducted through 20 January 2022 for studies evaluating the use of the NATEM assay in different clinical settings. The literature search yielded a total of 47 publications, 30 of which met the eligibility criteria for this review. Evaluation of NATEM's detecting ability for hemostasis disorders is limited in the literature. The results of the included studies indicate that NATEM seems to be a sensitive method for the detection of hyperfibrinolysis and may have an advantage in the diagnosis of hemostatic disorders. It could be more informative than the other ROTEM assays for detecting changes in coagulation parameters in patients who receive anticoagulants. However, the reported outcomes are highly varying among the included studies. NATEM has a high sensitivity to detect hypo- or hypercoagulability and provides a detailed insight into the whole hemostatic process from clot formation to clot breakdown. It could be a useful technique in variable fields of medicine, not only in adults, but also in pediatric and neonatal populations, to guide different hemostatic treatments and predict coagulation disorders or mortality/morbidity; this issue remains to be further investigated.
未激活血栓弹力图（NATEM）检测是一种即时检测方法，能够全面洞察实际的止血机制。然而，关于其在临床实践中的应用数据非常有限。本研究的目的是系统回顾文献，以获取有关NATEM在多种临床环境中应用的任何数据。通过对PubMed和Scopus数据库进行系统回顾，检索截至2022年1月20日评估NATEM检测在不同临床环境中应用的研究。文献检索共获得47篇出版物，其中30篇符合本综述的纳入标准。文献中对NATEM检测止血障碍能力的评估有限。纳入研究的结果表明，NATEM似乎是检测高纤溶状态的敏感方法，在止血障碍的诊断中可能具有优势。在检测接受抗凝治疗患者的凝血参数变化方面，它可能比其他血栓弹力图检测方法提供更多信息。然而，纳入研究报告的结果差异很大。NATEM对检测低凝或高凝状态具有高敏感性，并能详细洞察从凝血形成到凝血溶解的整个止血过程。它可能是医学各个领域中一种有用的技术，不仅适用于成人，也适用于儿科和新生儿群体，以指导不同的止血治疗并预测凝血障碍或死亡率/发病率；这一问题仍有待进一步研究。
