Voevodsky Institute of Chemical Kinetics and Combustion, 630090 Novosibirsk, Russia.
Department of Natural Sciences, Novosibirsk State University, 630090 Novosibirsk, Russia.
Int J Mol Sci. 2022 Mar 11;23(6):3060. doi: 10.3390/ijms23063060.
In this review, we provide an illustration of the idea discussed in the literature of using model compounds to study the effect of substitution of L- for D-amino acid residues in amyloid peptides. The need for modeling is due to the inability to study highly disordered peptides by traditional methods (high-field NMR, X-ray). At the same time, the appearance of such peptides, where L-amino acids are partially replaced by D-analogs is one of the main causes of Alzheimer's disease. The review presents examples of the use diastereomers with L-/D-tryptophan in model process-photoinduced electron transfer (ET) for studying differences in reactivity and structure of systems with L- and D-optical isomers. The combined application of spin effects, including those calculated using the original theory, fluorescence techniques and molecular modeling has demonstrated a real difference in the structure and efficiency of ET in diastereomers with L-/D-tryptophan residues. In addition, the review compared the factors governing chiral inversion in model metallopeptides and Aβ42 amyloid.
在这篇综述中，我们提供了一个使用模型化合物来研究在淀粉样肽中 L-对 D-氨基酸残基取代的影响的文献中讨论的想法的说明。需要建模是由于无法通过传统方法（高场 NMR、X 射线）研究高度无序的肽。同时，出现这种部分由 D-类似物取代 L-氨基酸的肽是阿尔茨海默病的主要原因之一。该综述介绍了使用 L-/D-色氨酸的非对映异构体在模型过程中光诱导电子转移 (ET) 的实例，用于研究具有 L-和 D-光学异构体的系统的反应性和结构差异。自旋效应的综合应用，包括使用原始理论计算的那些、荧光技术和分子建模已经证明了 L-/D-色氨酸残基的非对映异构体中 ET 的结构和效率的真正差异。此外，该综述比较了模型金属肽和 Aβ42 淀粉样蛋白中手性反转的控制因素。
