Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences in Sosnowiec, Medical University of Silesia, Kasztanowa 3, 41-200 Sosnowiec, Poland.
Int J Mol Sci. 2022 Mar 15;23(6):3141. doi: 10.3390/ijms23063141.
Ischemia-reperfusion injury is a key clinical problem of transplantology. Current achievements in optimizing organ rinse solutions and storage techniques have significantly influenced the degree of graft damage and its survival after transplantation. In recent years, intensive research has been carried out to maintain the viability of tissues and organs outside the integral environment of the body. Innovative solutions for improving the biochemical functions of the stored organ have been developed. The article discusses directions for modifying preservation solutions with antioxidants. Clinical and experimental studies aimed at optimizing these fluids, as well as perfusion and organ preservation techniques, are presented.
缺血再灌注损伤是移植学的一个关键临床问题。目前，优化器官冲洗液和储存技术的成就显著影响了移植后移植物的损伤程度及其存活。近年来，人们一直在进行密集的研究，以维持身体整体环境之外的组织和器官的活力。已经开发出了创新性的解决方案来改善储存器官的生化功能。本文讨论了用抗氧化剂来改良保存液的方向。本文介绍了旨在优化这些液体以及灌注和器官保存技术的临床和实验研究。
