Division of Internal Medicine, Department of Cardiology, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
Department of Emergency Medicine, Chang Gung Memorial Hospital, Chiayi 613, Taiwan.
Int J Environ Res Public Health. 2022 Mar 17;19(6):3558. doi: 10.3390/ijerph19063558.
Hepatitis C virus (HCV) infection is associated with a higher risk of chronic kidney disease (CKD). This study investigates the relationship among HCV, CKD, and understudied confounders, such as unhealthy behaviors and metabolic disturbances.
This cross-sectional study was conducted as part of a community health promotion program in an HCV endemic area of Taiwan from June to December 2019. Multivariable logistic regression analyses adjusted for demographic and clinical characteristics were performed to investigate the association between CKD and HCV seropositivity.
Of 2387 participants who underwent health check-ups, the mean age was 64.1 years old; females predominated (63.2%), and 306 (12.8%) subjects were seropositive for HCV. CKD, defined as a lower estimated glomerular filtration rate (eGFR) was associated with unhealthy dietary habits, metabolic syndrome, and HCV. Less frequent exercise, higher waist circumference (WC) and HbA1c all affected risk of CKD; HCV increased risk of CKD by 44% compared to non-HCV (OR 1.44, 95% confidence interval (CI) 1.05-1.98) in the multivariable analysis. In the HCV group, lower eGFR was also significantly associated with the severity of metabolic syndrome (MetS) (median eGFR was 86.4, 77.1, and 64.5 mL/min/1.73 m for individuals with three and five MetS components, respectively).
Beyond metabolic disturbance and irregular exercise, HCV seropositivity is independently associated with CKD in a community survey. Healthy lifestyle promotion might protect against renal function decline in HCV; however, the mechanisms underlying the association need further large-scale investigation.
丙型肝炎病毒（HCV）感染与慢性肾脏病（CKD）的风险增加有关。本研究调查了 HCV、CKD 和一些研究较少的混杂因素（如不健康的行为和代谢紊乱）之间的关系。
这项横断面研究是在 2019 年 6 月至 12 月在台湾 HCV 流行地区的社区健康促进计划中进行的。采用多变量逻辑回归分析调整了人口统计学和临床特征，以调查 CKD 与 HCV 血清阳性之间的关系。
在接受健康检查的 2387 名参与者中，平均年龄为 64.1 岁；女性居多（63.2%），306 名（12.8%）受试者 HCV 血清阳性。定义为估算肾小球滤过率（eGFR）较低的 CKD 与不健康的饮食习惯、代谢综合征和 HCV 有关。较少的运动、较高的腰围（WC）和 HbA1c 都会增加 CKD 的风险；与非 HCV 相比，HCV 使 CKD 的风险增加了 44%（OR 1.44，95%置信区间（CI）1.05-1.98）。在 HCV 组中，较低的 eGFR 也与代谢综合征（MetS）的严重程度显著相关（分别有三个和五个 MetS 成分的个体的 eGFR 中位数为 86.4、77.1 和 64.5 mL/min/1.73 m）。
除代谢紊乱和不规律运动外，HCV 血清阳性与社区调查中的 CKD 独立相关。促进健康的生活方式可能有助于预防 HCV 患者肾功能下降；然而，这种关联的机制需要进一步的大规模研究。
