德国一家三级护理医院中新冠病毒相关毛霉菌病的患病率
Prevalence of COVID-19 Associated Mucormycosis in a German Tertiary Care Hospital.
作者信息
Scharmann Ulrike, Herbstreit Frank, Steckel Nina Kristin, Dedy Jutta, Buer Jan, Rath Peter-Michael, Verhasselt Hedda Luise
机构信息
Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, 45122 Essen, Germany.
Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, 45122 Essen, Germany.
出版信息
J Fungi (Basel). 2022 Mar 17;8(3):307. doi: 10.3390/jof8030307.
Due to Coronavirus disease (COVID-19) a new group of patients at risk emerged with COVID-19-associated mucormycosis (CAM). Systematic studies, evaluating the prevalence of CAM are missing. To assess CAM prevalence in a tertiary care hospital in Germany, we applied direct microscopy, fungal culture and quantitative realtime in-house PCR targeting Mucorales-specific fragments of 18S and 28S rRNA on respiratory specimens of 100 critically ill COVID-19 patients. Overall, one Mucorales-PCR positive bronchoalevolar lavage was found whereas direct microscopy and fungal culture were negative in all cases. We conclude that a routine screening for CAM in Germany is not indicated.
由于冠状病毒病（COVID-19），出现了一组新的患有COVID-19相关毛霉菌病（CAM）的风险患者。目前缺少评估CAM患病率的系统性研究。为了评估德国一家三级护理医院中CAM的患病率，我们对100例危重症COVID-19患者的呼吸道标本应用了直接显微镜检查、真菌培养以及针对18S和28S rRNA的毛霉目特异性片段的定量实时内部PCR。总体而言，发现一份毛霉目PCR阳性的支气管肺泡灌洗标本，而所有病例的直接显微镜检查和真菌培养均为阴性。我们得出结论，在德国不建议对CAM进行常规筛查。
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