Khoo S K, Monks P L, Davies N T
Aust N Z J Obstet Gynaecol. 1986 May;26(2):129-35. doi: 10.1111/j.1479-828x.1986.tb01548.x.
A review of 24 patients with a molar placenta and coexisting live fetus, including 2 new cases from the Queensland Trophoblastic Disease Registry, was made. The rate of fetal abnormalities was 33%; all 8 abnormal fetuses were female and in 5 of them in whom cultures were performed the chromosomal karyotype was triploidy 69XXX. There were 3 patients in whom malignant sequelae were detected (12%). After a confident ultrasound diagnosis of a molar placenta and a coexisting live fetus, the decision on whether the pregnancy should be terminated or allowed to continue should be based on the likelihood of the fetus being abnormal. It is recommended that the chromosomal karyotype and amniotic fluid alpha-fetoprotein level be determined by amniocentesis at about 16-18 weeks. This should allow those pregnancies in whom the fetus is potentially normal to be selected for conservative management.
对24例存在葡萄胎胎盘且有存活胎儿的患者进行了回顾性研究，其中包括昆士兰滋养细胞疾病登记处的2例新病例。胎儿异常率为33%；所有8例异常胎儿均为女性，其中5例进行了染色体核型分析，核型为69XXX三倍体。有3例患者检测到恶性后遗症（12%）。在通过超声确诊为葡萄胎胎盘且有存活胎儿后，关于是否终止妊娠或继续妊娠的决定应基于胎儿异常的可能性。建议在孕16 - 18周左右通过羊膜穿刺术确定染色体核型和羊水甲胎蛋白水平。这将有助于筛选出胎儿可能正常的妊娠进行保守治疗。
