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Pathologically Entangled: Brain Trauma-Evoked ROS Imbalance Disrupts Kir Channel Function in Distant Peripheral Vessels.

作者信息

Weir Nick, Longden Thomas A

机构信息

Department of Physiology, School of Medicine, University of Maryland, Baltimore, MD, USA.

出版信息

Function (Oxf). 2021 Apr 22;2(3):zqab021. doi: 10.1093/function/zqab021. eCollection 2021.

DOI:10.1093/function/zqab021
PMID:35330675
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8788822/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08f5/8788822/8600c4bd1b28/zqab021f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08f5/8788822/8600c4bd1b28/zqab021f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08f5/8788822/8600c4bd1b28/zqab021f1.jpg

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Pathologically Entangled: Brain Trauma-Evoked ROS Imbalance Disrupts Kir Channel Function in Distant Peripheral Vessels.病理纠缠：脑外伤诱发的活性氧失衡破坏远处外周血管中的钾离子通道功能。
Function (Oxf). 2021 Apr 22;2(3):zqab021. doi: 10.1093/function/zqab021. eCollection 2021.
2
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本文引用的文献

1
Traumatic Brain Injury Impairs Systemic Vascular Function Through Disruption of Inward-Rectifier Potassium Channels.创伤性脑损伤通过破坏内向整流钾通道损害全身血管功能。
Function (Oxf). 2021;2(3). doi: 10.1093/function/zqab018. Epub 2021 Apr 6.
2
Impaired capillary-to-arteriolar electrical signaling after traumatic brain injury.创伤性脑损伤后毛细血管到动脉的电信号传递受损。
J Cereb Blood Flow Metab. 2021 Jun;41(6):1313-1327. doi: 10.1177/0271678X20962594. Epub 2020 Oct 13.
3
ATP- and voltage-dependent electro-metabolic signaling regulates blood flow in heart.
三磷酸腺苷（ATP）和电压依赖性电代谢信号调节心脏中的血流。
Proc Natl Acad Sci U S A. 2020 Mar 31;117(13):7461-7470. doi: 10.1073/pnas.1922095117. Epub 2020 Mar 13.
4
Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types.单细胞 RNA 测序分析小鼠脑和肺血管及血管相关细胞类型。
Sci Data. 2018 Aug 21;5:180160. doi: 10.1038/sdata.2018.160.
5
Endothelial GqPCR activity controls capillary electrical signaling and brain blood flow through PIP depletion.内皮细胞 GqPCR 活性通过 PIP 耗竭控制毛细血管电信号和脑血流。
Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):E3569-E3577. doi: 10.1073/pnas.1800201115. Epub 2018 Mar 26.
6
Capillary response to skeletal muscle contraction: evidence that redundancy between vasodilators is physiologically relevant during active hyperaemia.毛细血管对骨骼肌收缩的反应：在主动充血期间，血管扩张剂之间存在冗余是具有生理学相关性的证据。
J Physiol. 2018 Apr 15;596(8):1357-1372. doi: 10.1113/JP275467. Epub 2018 Mar 24.
7
Capillary K-sensing initiates retrograde hyperpolarization to increase local cerebral blood flow.毛细血管钾离子传感启动逆行性超极化以增加局部脑血流量。
Nat Neurosci. 2017 May;20(5):717-726. doi: 10.1038/nn.4533. Epub 2017 Mar 20.
8
Traumatic Brain Injury Causes Endothelial Dysfunction in the Systemic Microcirculation through Arginase-1-Dependent Uncoupling of Endothelial Nitric Oxide Synthase.创伤性脑损伤通过精氨酸酶-1依赖的内皮型一氧化氮合酶解偶联导致全身微循环中的内皮功能障碍。
J Neurotrauma. 2017 Jan 1;34(1):192-203. doi: 10.1089/neu.2015.4340. Epub 2016 Apr 1.
9
Vascular inward rectifier K+ channels as external K+ sensors in the control of cerebral blood flow.血管内向整流钾通道作为脑血流控制中的细胞外钾离子感受器。
Microcirculation. 2015 Apr;22(3):183-96. doi: 10.1111/micc.12190.
10
Inwardly rectifying potassium channels: their structure, function, and physiological roles.内向整流钾通道：结构、功能与生理作用。
Physiol Rev. 2010 Jan;90(1):291-366. doi: 10.1152/physrev.00021.2009.