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Can the Energetic Profile of Skeletal Muscle Predict Risk of Cognitive Impairment?

作者信息

Spangenburg Espen E

机构信息

Department of Physiology, Brody School of Medicine, East Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC 27834, USA.

出版信息

Function (Oxf). 2021 Nov 9;2(6):zqab057. doi: 10.1093/function/zqab057. eCollection 2021.

DOI:10.1093/function/zqab057
PMID:35330796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8788721/
Abstract
摘要

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本文引用的文献

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Mild Cognitive Impairment and Donepezil Impact Mitochondrial Respiratory Capacity in Skeletal Muscle.轻度认知障碍和多奈哌齐对骨骼肌线粒体呼吸能力的影响。
Function (Oxf). 2021 Sep 2;2(6):zqab045. doi: 10.1093/function/zqab045. eCollection 2021.
2
Peripheral Nerve Impairment in a Mouse Model of Alzheimer's Disease.阿尔茨海默病小鼠模型中的周围神经损伤
Brain Sci. 2021 Sep 20;11(9):1245. doi: 10.3390/brainsci11091245.
3
Protective effects of a small molecule inhibitor, DDQ against amyloid beta in Alzheimer's disease.小分子抑制剂 DDQ 对阿尔茨海默病中淀粉样β的保护作用。
Mitochondrion. 2021 Jul;59:17-29. doi: 10.1016/j.mito.2021.04.005. Epub 2021 Apr 9.
4
NAD boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle.NAD 提升可减少与年龄相关的淀粉样变性，并恢复肌肉中线粒体的动态平衡。
Cell Rep. 2021 Jan 19;34(3):108660. doi: 10.1016/j.celrep.2020.108660.
5
Mitochondrial Diagnostics: A Multiplexed Assay Platform for Comprehensive Assessment of Mitochondrial Energy Fluxes.线粒体诊断学：一种用于全面评估线粒体能量通量的多重分析平台。
Cell Rep. 2018 Sep 25;24(13):3593-3606.e10. doi: 10.1016/j.celrep.2018.08.091.
6
Mitochondrial oxygen consumption deficits in skeletal muscle isolated from an Alzheimer's disease-relevant murine model.阿尔茨海默病相关的小鼠模型骨骼肌中存在线粒体耗氧缺陷。
BMC Neurosci. 2014 Feb 13;15:24. doi: 10.1186/1471-2202-15-24.
7
Amyloid-β protein impairs Ca2+ release and contractility in skeletal muscle.淀粉样β蛋白会损害骨骼肌中的 Ca2+释放和收缩性。
Neurobiol Aging. 2010 Dec;31(12):2080-90. doi: 10.1016/j.neurobiolaging.2008.11.003. Epub 2008 Dec 23.
8
Elevated abeta42 in skeletal muscle of Alzheimer disease patients suggests peripheral alterations of AbetaPP metabolism.阿尔茨海默病患者骨骼肌中β淀粉样蛋白42水平升高表明β淀粉样前体蛋白代谢存在外周改变。
Am J Pathol. 2000 Mar;156(3):797-805. doi: 10.1016/s0002-9440(10)64947-4.