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Heating Up to Heal-Acute Heat Exposure Increases Hepatic Mitophagy Resulting in Hormetic Improvements in Mitochondrial Bioenergetic Efficiency.

作者信息

Fisher-Wellman Kelsey H

机构信息

Department of Physiology, East Carolina University, Brody School of Medicine, Greenville, NC 27834, USA.

East Carolina Diabetes and Obesity Institute, Greenville, NC 27834, USA.

出版信息

Function (Oxf). 2021 Feb 22;2(2):zqab011. doi: 10.1093/function/zqab011. eCollection 2021.

DOI:10.1093/function/zqab011
PMID:35330816
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8788751/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8788751/7ef7caa8d76c/zqab011f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8788751/7ef7caa8d76c/zqab011f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928e/8788751/7ef7caa8d76c/zqab011f1.jpg

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Heating Up to Heal-Acute Heat Exposure Increases Hepatic Mitophagy Resulting in Hormetic Improvements in Mitochondrial Bioenergetic Efficiency.升温以促进愈合——急性热暴露可增加肝脏线粒体自噬，从而对线粒体生物能量效率产生应激性改善。
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本文引用的文献

1
Heat Treatment Improves Hepatic Mitochondrial Respiratory Efficiency via Mitochondrial Remodeling.热处理通过线粒体重塑提高肝脏线粒体呼吸效率。
Function (Oxf). 2021 Jan 22;2(2):zqab001. doi: 10.1093/function/zqab001. eCollection 2021.
2
Liver-specific Prkn knockout mice are more susceptible to diet-induced hepatic steatosis and insulin resistance.肝特异性 Prkn 敲除小鼠更容易发生饮食诱导的肝脂肪变性和胰岛素抵抗。
Mol Metab. 2020 Nov;41:101051. doi: 10.1016/j.molmet.2020.101051. Epub 2020 Jul 10.
3
Metabolic landscape of the tumor microenvironment at single cell resolution.
肿瘤微环境的代谢全景图，单细胞分辨率。
Nat Commun. 2019 Aug 21;10(1):3763. doi: 10.1038/s41467-019-11738-0.
4
Hepatic mitochondrial adaptations to physical activity: impact of sexual dimorphism, PGC1α and BNIP3-mediated mitophagy.肝脏线粒体对体力活动的适应：性别二态性、PGC1α 和 BNIP3 介导的线粒体自噬的影响。
J Physiol. 2018 Dec;596(24):6157-6171. doi: 10.1113/JP276539. Epub 2018 Aug 28.
5
Heat shock protein 72 regulates hepatic lipid accumulation.热休克蛋白72调节肝脏脂质积累。
Am J Physiol Regul Integr Comp Physiol. 2018 Oct 1;315(4):R696-R707. doi: 10.1152/ajpregu.00073.2018. Epub 2018 Jun 20.
6
Production of superoxide and hydrogen peroxide from specific mitochondrial sites under different bioenergetic conditions.在不同生物能量条件下特定线粒体位点产生超氧化物和过氧化氢。
J Biol Chem. 2017 Oct 13;292(41):16804-16809. doi: 10.1074/jbc.R117.789271. Epub 2017 Aug 24.
7
Deficiency in the Heat Stress Response Could Underlie Susceptibility to Metabolic Disease.热应激反应缺陷可能是代谢疾病易感性的潜在原因。
Diabetes. 2016 Nov;65(11):3341-3351. doi: 10.2337/db16-0292. Epub 2016 Aug 23.
8
Metabolic Heterogeneity in Human Lung Tumors.人类肺部肿瘤中的代谢异质性
Cell. 2016 Feb 11;164(4):681-94. doi: 10.1016/j.cell.2015.12.034. Epub 2016 Feb 4.
9
BNip3 regulates mitochondrial function and lipid metabolism in the liver.BNip3 调节肝脏中的线粒体功能和脂质代谢。
Mol Cell Biol. 2012 Jul;32(13):2570-84. doi: 10.1128/MCB.00167-12. Epub 2012 Apr 30.
10
HSP72 protects against obesity-induced insulin resistance.热休克蛋白72可预防肥胖诱导的胰岛素抵抗。
Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1739-44. doi: 10.1073/pnas.0705799105. Epub 2008 Jan 25.