Petzoldt K, Müller E
Arzneimittelforschung. 1986 Jul;36(7):1085-8.
In an animal experimental study the effect of Saccharomyces cerevisiae (S.c.) Hansen CBS 5926 (Perenterol) on bacterial infections has been investigated using different forms of application. A significant protective effect after oronasal, intragastric and subcutaneous application of S.c. Hansen CBS 5926 has been found by challenge with Streptococcus pneumoniae and Escherichia coli. In order to investigate the possible mode of action the effect of S.c. Hansen CBS 5926 on chemiluminescence activity of polymorphonuclear cells from porcine blood has been studied. Isolated cells as well as cells in whole blood showed a significant induction of chemiluminescence. In comparison to Zymosan A the yeast cells originating from the commercial formulation showed a less pronounced ability to stimulate the chemiluminescence of blood cells. However, the stimulation was significantly enhanced after inactivation by heat.
在一项动物实验研究中，使用不同的给药形式研究了酿酒酵母（S.c.）汉森CBS 5926（培伦特罗）对细菌感染的影响。通过用肺炎链球菌和大肠杆菌进行攻击，发现经口鼻腔、胃内和皮下施用S.c.汉森CBS 5926后具有显著的保护作用。为了研究可能的作用方式，研究了S.c.汉森CBS 5926对猪血多形核细胞化学发光活性的影响。分离的细胞以及全血中的细胞均显示出化学发光的显著诱导。与酵母聚糖A相比，源自商业制剂的酵母细胞刺激血细胞化学发光的能力较弱。然而，加热灭活后刺激作用显著增强。
