卡托普利对硝普钠诱导的血浆去甲肾上腺素变化的影响。
Effect of captopril on changes in plasma noradrenaline induced by sodium nitroprusside.
作者信息
Becker R H, Struthers A D, Brown M J
出版信息
Br J Clin Pharmacol. 1986 Oct;22(4):409-13. doi: 10.1111/j.1365-2125.1986.tb02910.x.
Abstract
There is much animal data to suggest that angiotensin II has a regulatory role in noradrenaline release. We sought evidence for such a mechanism in man by pretreating six normal volunteers with captopril (50 mg) or placebo and then infusing them with incremental doses of sodium nitroprusside. Pretreatment with captopril had no significant effect on the mean arterial pressure, heart rate or plasma noradrenaline response to sodium nitroprusside, despite increasing plasma renin activity. This suggests that in normotensive salt replete man, normal levels of angiotensin II do not exert any tonic effect on noradrenaline release.
摘要
有大量动物数据表明，血管紧张素II在去甲肾上腺素释放中起调节作用。我们通过给六名正常志愿者预先服用卡托普利（50毫克）或安慰剂，然后给他们输注递增剂量的硝普钠，来寻找人类中这种机制的证据。尽管卡托普利预处理增加了血浆肾素活性，但对平均动脉压、心率或血浆去甲肾上腺素对硝普钠的反应没有显著影响。这表明，在血压正常且盐充足的人中，正常水平的血管紧张素II对去甲肾上腺素释放没有任何张力作用。
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