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Head-to-head comparison of different classes of FAP radioligands designed to increase tumor residence time: monomer, dimer, albumin binders, and small molecules vs peptides.不同类别的 FAP 放射性配体的头对头比较：旨在增加肿瘤滞留时间的单体、二聚体、白蛋白结合物和小分子与肽。
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Organotrifluoroborate enhances tumor targeting of fibroblast activation protein inhibitors for targeted radionuclide therapy.三氟硼酸盐增强成纤维细胞激活蛋白抑制剂的肿瘤靶向性用于放射性核素靶向治疗。
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State-of-the-art of nuclear medicine and molecular imaging in China: after the first 66 years (1956-2022).中国核医学与分子影像的发展现状：66年（1956 - 2022年）回顾
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1
Efficacy and Safety of Ac-PSMA-617-Targeted Alpha Therapy in Metastatic Castration-Resistant Prostate Cancer: A Systematic Review and Meta-Analysis.Ac-PSMA-617靶向α治疗在转移性去势抵抗性前列腺癌中的疗效和安全性：一项系统评价和荟萃分析
Front Oncol. 2022 Feb 3;12:796657. doi: 10.3389/fonc.2022.796657. eCollection 2022.
2
Dimeric FAPI with potential for tumor theranostics.具有肿瘤诊疗潜力的二聚体FAPI
Am J Nucl Med Mol Imaging. 2021 Dec 15;11(6):537-541. eCollection 2021.
3
Fibroblast Activation Protein (FAP) targeting homodimeric FAP inhibitor radiotheranostics: a step to improve tumor uptake and retention time.靶向成纤维细胞活化蛋白（FAP）的同二聚体FAP抑制剂放射诊疗剂：提高肿瘤摄取和保留时间的一步。
Am J Nucl Med Mol Imaging. 2021 Dec 15;11(6):476-491. eCollection 2021.
4
Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics.埃文斯蓝修饰的放射性标记成纤维细胞活化蛋白抑制剂作为长效癌症治疗药物。
Theranostics. 2022 Jan 1;12(1):422-433. doi: 10.7150/thno.68182. eCollection 2022.
5
First clinical experience of 106 cm, long axial field-of-view (LAFOV) PET/CT: an elegant balance between standard axial (23 cm) and total-body (194 cm) systems.106厘米长轴视野（LAFOV）PET/CT的首次临床经验：标准轴向（23厘米）和全身（194厘米）系统之间的完美平衡。
Eur J Nucl Med Mol Imaging. 2021 Nov;48(12):3755-3759. doi: 10.1007/s00259-021-05505-x.
6
Rational Design, Pharmacomodulation, and Synthesis of [Ga]Ga-Alb-FAPtp-01, a Selective Tumor-Associated Fibroblast Activation Protein Tracer for PET Imaging of Glioma.[Ga]Ga-Alb-FAPtp-01 的合理设计、药效修饰及合成：一种用于 PET 成像胶质瘤的肿瘤相关成纤维细胞激活蛋白示踪剂
ACS Sens. 2021 Sep 24;6(9):3424-3435. doi: 10.1021/acssensors.1c01316. Epub 2021 Aug 20.
7
Feasibility and Therapeutic Potential of 177Lu-Fibroblast Activation Protein Inhibitor-46 for Patients With Relapsed or Refractory Cancers: A Preliminary Study.177Lu-成纤维细胞激活蛋白抑制剂-46用于复发或难治性癌症患者的可行性及治疗潜力：一项初步研究
Clin Nucl Med. 2021 Nov 1;46(11):e523-e530. doi: 10.1097/RLU.0000000000003810.
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State-of-the-art of FAPI-PET imaging: a systematic review and meta-analysis.FAPI-PET 成像的最新技术：系统评价和荟萃分析。
Eur J Nucl Med Mol Imaging. 2021 Dec;48(13):4396-4414. doi: 10.1007/s00259-021-05475-0. Epub 2021 Jun 25.
9
Dynamic PET imaging with ultra-low-activity of F-FDG: unleashing the potential of total-body PET.超低活度F-FDG动态PET成像：释放全身PET的潜力
Eur J Nucl Med Mol Imaging. 2021 Dec;48(13):4138-4141. doi: 10.1007/s00259-021-05214-5.
10
The Latest Developments in Imaging of Fibroblast Activation Protein.成纤维细胞激活蛋白成像的最新进展。
J Nucl Med. 2021 Feb;62(2):160-167. doi: 10.2967/jnumed.120.244806. Epub 2020 Oct 30.

Enhancing fibroblast activation protein (FAP)-targeted radionuclide therapy with albumin binding, and beyond.

作者信息

Younis Muhsin H, Malih Sara, Lan Xiaoli, Rasaee Mohammad Javad, Cai Weibo

机构信息

Departments of Radiology and Medical Physics, University of Wisconsin - Madison, Madison, WI, USA.

Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

出版信息

Eur J Nucl Med Mol Imaging. 2022 May;49(6):1773-1777. doi: 10.1007/s00259-022-05766-0.

DOI:10.1007/s00259-022-05766-0
PMID:35332379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9074086/
Abstract
摘要