Stentebjerg Louise L, Madsen Lene R, Støving René K, Juhl Claus B, Vinter Christina A, Andersen Lise Lotte T, Renault Kristina, Jensen Dorte M
Steno Diabetes Center Odense, Odense University Hospital, Kløvervænget 10, DK-5000, 0045 40258265, Odense C, Denmark.
Department of Clinical Research, University of Southern Denmark, J.B. Winsløws Vej 19,3, 5000, Odense C, Denmark.
Obes Surg. 2022 Jun;32(6):2047-2055. doi: 10.1007/s11695-022-06021-z. Epub 2022 Mar 24.
The aims of this systematic review were to identify the prevalence of hypoglycemia among pregnant women treated with gastric bypass, and risk factors of hypoglycemic events in pregnancy. We searched MEDLINE, EMBASE, Cochrane, and Scopus databases from inception to April 6, 2021. Six studies investigating glucose metabolism in pregnancy following gastric bypass were included (n = 330). As assessed by the oral glucose tolerance test and continuous glucose monitoring, 57.6% (95% CI [40.1, 75.1]) of women with gastric bypass were exposed to hypoglycemia during pregnancy. No studies performed the mixed meal test, and no studies reported on risk factors associated with hypoglycemia. Further studies are required to determine the magnitude of hypoglycemia in these women's everyday-life using continuous glucose monitoring and mixed meal test.
本系统评价的目的是确定接受胃旁路手术治疗的孕妇中低血糖的患病率以及孕期低血糖事件的危险因素。我们检索了MEDLINE、EMBASE、Cochrane和Scopus数据库，检索时间从各数据库建库至2021年4月6日。纳入了6项调查胃旁路术后孕期葡萄糖代谢的研究（n = 330）。通过口服葡萄糖耐量试验和持续葡萄糖监测评估，57.6%（95%可信区间[40.1, 75.1]）接受胃旁路手术的女性在孕期出现低血糖。没有研究进行混合餐试验，也没有研究报告与低血糖相关的危险因素。需要进一步的研究，使用持续葡萄糖监测和混合餐试验来确定这些女性日常生活中低血糖的严重程度。
