Appl Opt. 2022 Mar 20;61(9):2371-2381. doi: 10.1364/AO.449908.
Accurate, in-field-compatible, sensing based on near infrared spectroscopy (NIRS) requires development of instrumentation with low noise and long-term stability. Here, we present a fully fiber-optic spectroscopy setup using a supercontinuum source in the long-pulse regime (2 ns) and a balanced detector scheme to demonstrate high-accuracy NIRS-based sensing. The noise sources of the system are studied theoretically and experimentally. The relative intensity noise was reduced from typical values up to 6% to less than 0.1% by deploying a balanced detector and averaging. At well-balanced wavelengths, the system without transmission cells achieved a signal to noise ratio (SNR) above 70 dB, approaching the shot noise limit. With transmission cells and long-term measurements, the overall SNR was 55 dB. Glucose in physiological concentrations was measured as a model system, yielding a root mean square error of 4.8 mM, approaching the needed accuracy for physiological glucose monitoring.
基于近红外光谱(NIRS)的准确、现场兼容的传感需要开发具有低噪声和长期稳定性的仪器。在这里,我们提出了一种完全光纤光谱学设置,使用长脉冲(2ns)超连续源和平衡探测器方案来演示基于近红外光谱的高精度传感。系统的噪声源进行了理论和实验研究。通过部署平衡探测器和平均,相对强度噪声从典型值高达 6%降低到小于 0.1%。在波长平衡良好的情况下,没有传输单元的系统达到了 70dB 以上的信噪比(SNR),接近散粒噪声极限。使用传输单元和长期测量,整体 SNR 为 55dB。以生理浓度的葡萄糖作为模型系统进行测量,得到 4.8mM 的均方根误差,接近生理葡萄糖监测所需的精度。