Barrett J D, Eggena P
Clin Exp Hypertens A. 1986;8(7):1171-8. doi: 10.3109/10641968609045480.
The purpose of this study was to determine the influence acute stress on the plasma levels of active and inactive renin in the rat. Active and inactive plasma renins were measured in calm unanesthetized normal Wistar rats (indwelling catheter) and compared to values obtained after handling, anesthesia and decapitation. All maneuvers resulted in an increase of active renin. Only anesthesia significantly reduced inactive renin. It is concluded that acute stress can significantly change the ratio of active and inactive renins in rat plasma. These changes must be taken into consideration when the influence of "physiological or pharmacological" alterations of these enzymes are under investigation.
本研究的目的是确定急性应激对大鼠血浆中活性肾素和非活性肾素水平的影响。在平静未麻醉的正常Wistar大鼠（留置导管）中测量活性和非活性血浆肾素，并与处理、麻醉和断头后获得的值进行比较。所有操作均导致活性肾素增加。只有麻醉显著降低了非活性肾素。得出的结论是，急性应激可显著改变大鼠血浆中活性肾素与非活性肾素的比例。在研究这些酶的“生理或药理”改变的影响时，必须考虑这些变化。
