Trenchs Gisela, Diaba Faïza
Laboratori de Química Orgànica, Facultat de Farmàcia, IBUB, Universitat de Barcelona, Av. Joan XXIII 27-31, 08028-Barcelona, Spain.
Org Biomol Chem. 2022 Apr 13;20(15):3118-3123. doi: 10.1039/d2ob00276k.
The first blue light-mediated synthesis of γ- and δ-lactams from trichloroacetamides is reported in the presence of -Ir(ppy). Unlike previous works, these reactions are achieved under an air atmosphere with non-anhydrous solvents and even in water. Moreover, we have demonstrated that the solvent can be the hydrogen donor in the radical process which opens up new insights into these radical transformations and the reaction mechanisms involved.
据报道，在-Ir(ppy)存在的情况下，首次实现了通过蓝光介导三氯乙酰胺合成γ-和δ-内酰胺。与之前的工作不同，这些反应是在空气气氛下，使用非无水溶剂甚至在水中实现的。此外，我们已经证明，在自由基过程中溶剂可以作为氢供体，这为这些自由基转化及其涉及的反应机制开辟了新的见解。
