Department of Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Hunan Engineering Research Center of Targeted Therapy for Hematopoietic Malignancies, Changsha, Hunan, China.
Clin Transl Oncol. 2022 Aug;24(8):1501-1514. doi: 10.1007/s12094-022-02820-z. Epub 2022 Mar 25.
Small B-cell lymphoma is the classification of B-cell chronic lymphoproliferative disorders that include chronic lymphocytic leukaemia/small lymphocytic lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, lymphoplasmacytic lymphoma/Waldenstrom macroglobulinemia. The clinical presentation is somewhat heterogeneous, and its occurrence and development mechanisms are not yet precise and may involve epigenetic changes. Epigenetic alterations mainly include DNA methylation, histone modification, and non-coding RNA, which are essential for genetic detection, early diagnosis, and assessment of treatment resistance in small B-cell lymphoma. As chronic lymphocytic leukemia/small lymphocytic lymphoma has already been reported in the literature, this article focuses on small B-cell lymphomas such as follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, and Waldenstrom macroglobulinemia. It discusses recent developments in epigenetic research to diagnose and treat this group of lymphomas. This review provides new ideas for the treatment and prognosis assessment of small B-cell lymphoma by exploring the connection between small B-cell lymphoma and epigenetics.
小 B 细胞淋巴瘤是 B 细胞慢性淋巴增殖性疾病的分类，包括慢性淋巴细胞白血病/小淋巴细胞淋巴瘤、滤泡性淋巴瘤、套细胞淋巴瘤、边缘区淋巴瘤、淋巴浆细胞淋巴瘤/华氏巨球蛋白血症。临床表现具有一定的异质性，其发生发展机制尚不完全明确，可能涉及表观遗传改变。表观遗传改变主要包括 DNA 甲基化、组蛋白修饰和非编码 RNA，这些改变对于小 B 细胞淋巴瘤的基因检测、早期诊断和治疗耐药评估至关重要。由于慢性淋巴细胞白血病/小淋巴细胞淋巴瘤已在文献中报道，本文主要关注滤泡性淋巴瘤、套细胞淋巴瘤、边缘区淋巴瘤和华氏巨球蛋白血症等小 B 细胞淋巴瘤，讨论了表观遗传学研究在诊断和治疗这组淋巴瘤方面的最新进展。通过探讨小 B 细胞淋巴瘤与表观遗传学之间的联系，为小 B 细胞淋巴瘤的治疗和预后评估提供了新思路。
