Department of Gastroenterology, Takeda General Hospital, Aizuwakamatsu 965-8585, Japan.
Department of Gastroenterology, Dokkyo Medical University, Mibu 321-0293, Japan.
Medicina (Kaunas). 2022 Mar 10;58(3):410. doi: 10.3390/medicina58030410.
A 60-year-old woman was diagnosed with nonfunctional pancreatic neuroendocrine neoplasm with multiple liver metastases and was administered everolimus. Due to persistent epigastric pain and diarrhea, a colonoscopy was performed on the 14th day after the start of everolimus administration, which revealed small bleeding ulcers in the ileocecal region, transverse colon, and rectum. These adverse effects were attributed to the everolimus; it was immediately discontinued, and the patient's clinical symptoms and imaging findings improved. We concurred that the administration of calcium channel blockers resulted in the inhibition of everolimus metabolism and the disease onset. The everolimus was discontinued. There was no subsequent recurrence of hemorrhagic colitis.
一位 60 岁女性被诊断为无功能性胰腺神经内分泌肿瘤，伴多发肝转移，给予依维莫司治疗。由于持续的上腹痛和腹泻，在开始使用依维莫司治疗的第 14 天进行了结肠镜检查，发现回盲部、横结肠和直肠有小的出血性溃疡。这些不良反应归因于依维莫司；依维莫司立即停用，患者的临床症状和影像学发现得到改善。我们一致认为钙通道阻滞剂的使用导致了依维莫司代谢的抑制和疾病的发生。依维莫司停药后，未再发生出血性结肠炎的复发。
