Mestres Júlia, Leonardi Francesca, Mathwig Klaus
Stichting Imec Nederland within OnePlanet Research Center, Bronland 10, 6708 WH Wageningen, The Netherlands.
School of Chemistry, University College Cork, Kane Building, T12 YN60 Cork, Ireland.
Micromachines (Basel). 2022 Feb 25;13(3):362. doi: 10.3390/mi13030362.
Electrochemical sensors are powerful tools for the detection and real-time monitoring of a wide variety of analytes. However, the long-term operation of Faradaic sensors in complex media is challenging due to fouling. The protection of the electrode surface during in vivo operation is a key element for improving the monitoring of analytes. Here, we study different EUDRAGIT controlled release acrylate copolymers for protecting electrode surfaces. The dissolution of these polymers-namely EUDRAGIT L 30 D-55 and EUDRAGIT FS 30 D-is triggered by a change in pH of the environment, and it is electrochemically monitored by detecting electrode access by means of a redox probe. The full dissolution of the polymer is achieved within 30 min and the electrode response indicates a complete recovery of the original electrochemical performance. We demonstrate that amperometric sensing is a practical and straightforward technique for real-time and in situ sensing of EUDRAGIT dissolution profiles. It will find future applications in determining the protection of polymer electrode coating in real matrices and in vivo applications.
电化学传感器是用于检测和实时监测多种分析物的强大工具。然而，由于污垢的存在，法拉第传感器在复杂介质中的长期运行具有挑战性。体内操作期间电极表面的保护是改善分析物监测的关键因素。在此，我们研究了用于保护电极表面的不同聚丙烯酸树脂控释丙烯酸酯共聚物。这些聚合物（即聚丙烯酸树脂L 30 D-55和聚丙烯酸树脂FS 30 D）的溶解是由环境pH值的变化触发的，并通过使用氧化还原探针检测电极通路进行电化学监测。聚合物在30分钟内完全溶解，电极响应表明原始电化学性能完全恢复。我们证明，安培传感是一种用于实时原位传感聚丙烯酸树脂溶解曲线的实用且直接的技术。它将在确定实际基质和体内应用中聚合物电极涂层的保护方面找到未来的应用。
