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资源匮乏地区用于新冠病毒血清学检测的改良血凝试验：准备好进入黄金时段了吗？

Modified Hemagglutination Tests for COVID-19 Serology in Resource-Poor Settings: Ready for Prime-Time?

作者信息

Focosi Daniele, Franchini Massimo, Maggi Fabrizio

机构信息

North-Western Tuscany Blood Bank, Pisa University Hospital, 56124 Pisa, Italy.

Division of Transfusion Medicine, Carlo Poma Hospital, 46100 Mantua, Italy.

出版信息

Vaccines (Basel). 2022 Mar 8;10(3):406. doi: 10.3390/vaccines10030406.

DOI:10.3390/vaccines10030406
PMID:35335038
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8953758/
Abstract

During the ongoing COVID-19 pandemic, serology has suffered several manufacturing and budget bottlenecks. Kode technology exposes exogenous antigens on the surface of cells; in the case of red blood cells, modified cells are called kodecytes, making antibody-antigen reactions detectable by the old-fashioned hemagglutination test. In this commentary, we review evidence supporting the utility of SARS-CoV-2 Spike kodecytes for clinical diagnostic purposes and serosurveys in resource-poor settings.

摘要

在持续的新冠疫情期间，血清学面临着多个生产和预算瓶颈。Kode技术可使外源性抗原暴露于细胞表面；就红细胞而言，经过改造的细胞被称为编码红细胞，从而使抗体-抗原反应能够通过传统的血凝试验检测出来。在这篇评论文章中，我们综述了支持将新冠病毒刺突蛋白编码红细胞用于临床诊断及资源匮乏地区血清学调查的证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dc4/8953758/65c07e83faf2/vaccines-10-00406-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dc4/8953758/65c07e83faf2/vaccines-10-00406-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7dc4/8953758/65c07e83faf2/vaccines-10-00406-g001.jpg

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