Missale C, Liberini P, Memo M, Carruba M O, Spano P
Endocrinology. 1986 Nov;119(5):2227-32. doi: 10.1210/endo-119-5-2227.
Dopamine (DA) may participate in the control of aldosterone secretion. We report that two different receptors for DA are present in rat adrenal glomerulosa: D-1, associated with stimulation of adenylate cyclase, and D-2, whose action inhibits adenylate cyclase. The adenylate cyclase system was stimulated by DA (EC50, 7.2 microM) and different DA agonists. When the D-1 receptor blocker SCH 23390 was added to the incubation medium, DA elicited a dose-dependent inhibition of adenylate cyclase (IC50, 10 microM); (-)sulpiride specifically blocked this effect. Furthermore, DA blocked angiotensin II-induced aldosterone release from glomerulosa slices in vitro. This effect was prevented by (-)sulpiride, but not by SCH 23390. The results suggest that the D-2 receptor acts to inhibit the cAMP-generating system and may be physiologically involved in the regulation of aldosterone secretion.
多巴胺（DA）可能参与醛固酮分泌的调控。我们报告大鼠肾上腺球状带中存在两种不同的DA受体：与腺苷酸环化酶刺激相关的D-1受体，以及其作用抑制腺苷酸环化酶的D-2受体。腺苷酸环化酶系统受到DA（半数有效浓度，7.2微摩尔）和不同DA激动剂的刺激。当将D-1受体阻滞剂SCH 23390添加到孵育培养基中时，DA引发了腺苷酸环化酶的剂量依赖性抑制（半数抑制浓度，10微摩尔）；（-）舒必利特异性阻断了这种效应。此外，DA在体外阻断了血管紧张素II诱导的球状带切片醛固酮释放。这种效应被（-）舒必利阻止，但未被SCH 23390阻止。结果表明，D-2受体起到抑制cAMP生成系统的作用，并且可能在生理上参与醛固酮分泌的调节。
