Liu Ziyue, Kaliaperumal Kumaravel, Chen Hongfeng, Zhang Jun
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Science, Guangzhou, China.
National Engineering Research Center of Navel Orange, Gannan Normal University, Ganzhou, China.
Nat Prod Res. 2022 Dec;36(23):6143-6149. doi: 10.1080/14786419.2022.2056892. Epub 2022 Mar 25.
In this study, the anti-inflammatory effect of the water extract of leaf (WESCL) was evaluated for the first time. WESCL exhibited anti-inflammatory activity by significantly reducing the cell metamorphosis, the production of nitric oxide (NO), and reactive oxygen species (ROS) in LPS-stimulated RAW 264.7 macrophages while showing no cytotoxic effect to the cells. Furthermore, an study revealed that WESCL could alleviate the disease development of osteoarthritis (OA) and decrease the level of interleukin-6 (IL-6) in mice. Chemical composition analysis indicated that WESCL contained high amounts of phenolic compounds, flavonoids, and triterpenoid saponins, with the total content being 30.6 mg gallic acid equivalent (GAE)/g, 38.2 mg quercetin equivalent (QE)/g, 100.5 mg oleanolic acid equivalent (OAE)/g, respectively. The present study successfully identified WESCL as a naturally-occurring anti-inflammatory agent, supporting its potent application for the treatment of inflammation-related diseases.
在本研究中，首次评估了叶水提取物（WESCL）的抗炎作用。WESCL通过显著减少脂多糖刺激的RAW 264.7巨噬细胞中的细胞变形、一氧化氮（NO）和活性氧（ROS）的产生而表现出抗炎活性，同时对细胞无细胞毒性作用。此外，一项研究表明，WESCL可以减轻小鼠骨关节炎（OA）的疾病发展并降低白细胞介素-6（IL-6）水平。化学成分分析表明，WESCL含有大量的酚类化合物、黄酮类化合物和三萜皂苷，其总含量分别为30.6毫克没食子酸当量（GAE）/克、38.2毫克槲皮素当量（QE）/克、100.5毫克齐墩果酸当量（OAE）/克。本研究成功地将WESCL鉴定为一种天然存在的抗炎剂，支持其在治疗炎症相关疾病方面的有效应用。
