Chan Zuckerberg Biohub and Department of Biochemistry and Biophysics, University of California, San Francisco, CA, United States.
Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA, United States.
Curr Top Dev Biol. 2022;147:73-91. doi: 10.1016/bs.ctdb.2022.01.001. Epub 2022 Mar 11.
Choanoflagellates, the closest living relatives of animals, have the potential to reveal the genetic and cell biological foundations of complex multicellular development in animals. Here we describe the history of research on the choanoflagellate Salpingoeca rosetta. From its original isolation in 2000 to the establishment of CRISPR-mediated genome editing in 2020, S. rosetta provides an instructive case study in the establishment of a new model organism.
领鞭虫，动物最亲近的现存亲属，有可能揭示动物复杂多细胞发育的遗传和细胞生物学基础。在这里，我们描述了对领鞭虫 Salpingoeca rosetta 的研究历史。从 2000 年最初分离到 2020 年建立 CRISPR 介导的基因组编辑，S. rosetta 为建立新的模式生物提供了一个有指导意义的案例研究。
