Department of Molecular and Cell Biology, University of Cape Town, Cape Town, South Africa.
Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, Western Australia WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; Department of Microbiology, PathWest Laboratory Medicine, Nedlands, WA, Australia; School of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia.
Anaerobe. 2022 Apr;74:102549. doi: 10.1016/j.anaerobe.2022.102549. Epub 2022 Mar 23.
Clostridioides (Clostridium) difficile infection (CDI) places a burden on healthcare facilities worldwide. Most research studies have been concentrated in high-income countries in North America, Europe, Asia and Australia, where C. difficile is the leading cause of diarrhoea associated with antimicrobial use. This narrative review summarises African CDI studies, focussing on reports published in the last 20 years. Although relatively sparse, the data suggest that CDI is an important cause of diarrhoea on the continent. African CDI patient populations are often younger than in European and North American settings, probably due to the high prevalence of co-morbid conditions such as tuberculosis, particularly in sub-Saharan Africa. Strain typing data are rare and where reported generally limited to single sites and institutions. Despite challenges, including a lack of facilities and awareness, there is a need for further investigation to more accurately determine the true burden of disease caused by C. difficile in Africa.
艰难梭菌（梭状芽孢杆菌）感染（CDI）给全球医疗机构带来了负担。大多数研究集中在北美、欧洲、亚洲和澳大利亚的高收入国家，在这些国家，艰难梭菌是与抗菌药物使用相关的腹泻的主要原因。本叙述性综述总结了非洲艰难梭菌感染的研究，重点是过去 20 年发表的报告。尽管数据相对较少，但这些数据表明 CDI 是非洲大陆腹泻的一个重要原因。非洲 CDI 患者人群通常比欧洲和北美人群年轻，这可能是由于合并症（如结核病）的高患病率所致，特别是在撒哈拉以南非洲。菌株分型数据很少，而且报告的情况通常仅限于单个地点和机构。尽管存在设施和意识不足等挑战，但仍需要进一步调查，以更准确地确定非洲艰难梭菌感染所造成疾病的真实负担。
